Oxford University researchers have discovered what causes a switch to flip in our brains and wake us up. The discovery, published in the journal Nature, brings us closer to understanding the mystery of sleep.

Sleep is governed by two systems--the circadian clock and the sleep homeostat. While the circadian clock is quite well understood, very little is known about the sleep homeostat.

Professor Gero Miesenböck, in whose laboratory the new research was conducted, explained: 'The circadian clock allows us to anticipate predictable changes in our environment that are caused by the Earth's rotation. As such, it makes sure we do our sleeping when it hurts us least, but it doesn't speak to the mystery of why we need to sleep in the first place.

For a cell in an embryo, the secret to becoming part of the baby's body instead of the placenta is to contract more and carry on dancing, scientists at EMBL have found. The study, published today in Nature, could one day have implications for assisted reproduction.

After a sperm cell fertilises an egg cell, that fertilised egg divides repeatedly, forming a ball of cells. Shortly before the embryo implants in the womb, some of those cells move inwards. These are the cells that will develop into all the baby's body parts. The cells left on the surface will become the placenta, connecting the embryo to the mother's uterus.

University of California, Berkeley engineers have built the first dust-sized, wireless sensors that can be implanted in the body, bringing closer the day when a Fitbit-like device could monitor internal nerves, muscles or organs in real time.

Because these batteryless sensors could also be used to stimulate nerves and muscles, the technology also opens the door to "electroceuticals" to treat disorders such as epilepsy or to stimulate the immune system or tamp down inflammation.

PHILADELPHIA - Reprogramming of the molecular pathways underlying normal metabolism is essential for T cell infection-fighting function and for the immune system to form a "memory" of the microbes it has already encountered. But exactly how metabolism in exhausted T cells is maintained in chronic infections and cancer is a missing element in this line of research. Now, a new study suggests that tweaking metabolic steps in combination with checkpoint blockade drugs may improve some cancer therapies, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The team published their findings this week in Immunity.

Excess nitrogen from agricultural runoff can enter surface waters with devastating effects. Algal blooms and fish kills are a just a couple of possible consequences. But riparian buffer zones - areas of grasses, perennials, or trees - between farmlands and streams or rivers can help.

"Riparian buffer zones are nature's hydraulic shock absorbers," says Deanna Osmond, a soil scientist at North Carolina State University. They can reduce pollution and provide habitat for wildlife. Trees can hold stream banks together and provide food for animals. These buffer zones can also dampen the flow of agricultural runoff. This can lead to lower amounts of nitrogen reaching streams and rivers.

BOSTON - Lung cancer is the most common cause of cancer deaths, accounting for about a third of all tumor-related deaths. Adenocarcinomas, a non-small cell lung cancer (NSCLC), account for about 40 percent of cancer diagnoses, but few treatments are available for the disease.