How much alcohol you drink and how hard it affects you are rooted in your DNA, specifically, a “lazy” variant of the Alcohol Dehydrogenase 1B (ADH1B) gene, known to regulate the activity of a key group of enzymes.When we drink, the alcohol rushes into our bloodstream, where the alcohol dehydrogenase enzymes metabolize, or break down, the ethanol into acetaldehyde. If this happens quickly, lots of acetaldehyde accumulates in a short amount of time, which can lead to adverse effects such as flushing, nausea, and headaches. Conversely, if the ethanol is metabolized slowly, the alcohol remains intact in the blood for longer periods, prolonging its more pleasant, euphoric effects.