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How Salmonella Survives Macrophage's Acid Attack

How Salmonella Survives Macrophage's Acid Attack

Macrophages destroy bacteria by engulfing them in intracellular compartments, which they then acidify to kill or neutralize the bacteria.
Some pathogenic bacteria, such as Salmonella enterica, have evolved to exist and even grow within these acidified compartments. Yet, how Salmonella responds to the acidic environment and how that environment affects the virulence of this pathogen are unclear. New research reveals that Salmonella fights acid with acid, by lowering the pH of its own interior in response to the acidification of the Salmonella-containing compartment by the macrophage, and by using that low pH as a signal to turn on genes needed to establish an infection.

Typhoon Haiyan May Contaminate Philippines Aquifer For Years

Typhoon Haiyan May Contaminate Philippines Aquifer For Years

In 2013, Typhoon Haiyan killed more than 6,000 people and destroying nearly $3 billion worth of property in the Philippines. While the country is still recovering from the storm, researchers have found that an aquifer on the island of Samar inundated with salt water by the storm surge could remain undrinkable for up to 10 years - a second aquifer on the island that was also inundated has recovered much more quickly.
Geology and infrastructure play key roles in determining whether aquifers that provide drinking water are inundated with seawater during a typhoon or hurricane and how long the contamination lasts.

Genetic Modification Led To Maize Roots Evolving To Be More Nitrogen Efficient

Genetic Modification Led To Maize Roots Evolving To Be More Nitrogen Efficient

Genetic modification of maize over the last century has led to desirable shoot characteristics and increased yield - and that likely contributed to the evolution of root systems that are more efficient in acquiring nutrients, such as nitrogen, from the soil, according to a new study. About half of the yield gains in commercial corn in the last 100 years has come from improved plant genetics, explained Larry York, a postdoctoral research fellow at the University of Nottingham. The other half came largely from agronomic practices, such as fertilizer use and higher planting densities. 

Professional Golf: For Most It Is A Lonely Life On A Meager Income

Professional Golf: For Most It Is A Lonely Life On A Meager Income

If you just watched the Master's Tournament in Augusta, Georgia, you saw the second-youngest player ever to win. That is a pretty good way for a young man to spend the next year.But for most golfers, like most young baseball players, the reality is much different. An EPGA tour player for 12 years commented to Dr. John Fry of Myerscough College on the life: "The word that jumps in my head is lonely".

LEM - Newly Discovered Protein Boosts Immunity To Cancer

LEM - Newly Discovered Protein Boosts Immunity To Cancer

A newly discovered protein plays a central role in promoting immunity to viruses and cancer, according to experiments in mice and human cells.  The hitherto unknown protein, which the researchers named lymphocyte expansion molecule, or LEM, modulates the proliferation of human T cells as well as in mice, by promoting the proliferation of cytotoxic T cells, which kill cancer cells and cells infected with viruses. The discovery was unexpected because the new protein had no known function and doesn't resemble any other protein. Researchers from Imperial College London who led the study are now developing a gene therapy designed to boost the infection-fighting cells, and hope to begin human trials in three years. 

Do All These Health Awareness Day Campaigns Actually Help Anyone?

Do All These Health Awareness Day Campaigns Actually Help Anyone?

In 2014, there were almost 200 health awareness days, weeks or months on the 2014 U.S. Department of Health and Human Services' National Health Observances calendar.  Since there are only 250 days in a working year, that means one day each week was not given over to some kind of health awareness effort. H.H.S. says their mission is to advocate for "evidence-based" interventions for health problems, so what evidence did they use that 200 health "awareness" campaigns were making a difference? Are they really helping anyone, or is it just less-successful attempts to get people to dump water on their own heads?

No Batteries Required - New Camera Runs Forever

No Batteries Required - New Camera Runs Forever

A research team has created a prototype video camera that is fully self-powered.

Solar panels and digital cameras obviously have different purposes - one converts light to power while the other simply measures it - but both are constructed from essentially the same components. At the heart of any digital camera is an image sensor, a chip with millions of pixels. The key enabling device in a pixel is the photodiode, which produces an electric current when exposed to light. This mechanism enables each pixel to measure the intensity of light falling on it. The same photodiode is also used in solar panels to convert incident light to electric power. 

SAYE: Herbal Tea Combats Malaria

SAYE: Herbal Tea Combats Malaria

Malaria is a critical health problem in West Africa, 11 percent of deaths are related to it, but for a variety of reasons they have more confidence in alternative medicine than they do modern health care practices. 
However, some herbal medicines work and an analysis of the pharmacological properties of an herbal medication derived from Cochlospermum planchonii (a shrubby weed known as N'Dribala), Phyllanthus amarus and Cassia alata shows that it may be the case with SAYE, which means “jaundice” in the Dioula language. 

Recurrent Miscarriages Could Be Linked To Body Clock Genes

Recurrent Miscarriages Could Be Linked To Body Clock Genes

It is estimated that 5% of women experience two clinical miscarriages and approximately 1% suffer three or more losses. 
Researchers at the University of Warwick and University Hospitals Coventry and Warwickshire (UHCW) NHS Trust have found that body clock genes could affect women's ability to have children. The study pinpoints how body clock genes are temporarily switched off in the lining of the womb to allow an embryo to implant. Timing of this event is critical for pregnancy. 

Why Not Ask The Public What Works To Get People Into Clinical Trials?

Why Not Ask The Public What Works To Get People Into Clinical Trials?

While a debate was raging between scientists and government regulators on how best to explain to patients the risks of participating in clinical research studies that compare standardized treatments, a team of bioethicists boldly went where no experts had gone before -- to the public.
The response? Keep it simple, but always ask permission, even when the research only involves gathering data from anonymized medical records. 

Cannabidiol: Marijuana Extract May Bring Hope For Children With Severe Epilepsy

Cannabidiol: Marijuana Extract May Bring Hope For Children With Severe Epilepsy

A liquid form of marijuana shows promise as a treatment for children with severe epilepsy, according to a study released today which involved 213 people, ranging from toddlers to adults, with a median age of 11 who had severe epilepsy that did not respond to other treatments.
Participants had Dravet syndrome and Lennox-Gastaut syndrome, epilepsy types that can lead to intellectual disability and lifelong seizures, as well as 10 other types of severe epilepsy. 

Want To Get Men Donating Online? Feature A Woman And Make It Competitive

Want To Get Men Donating Online? Feature A Woman And Make It Competitive

A real-world analysis of human behavior finds that men treat online giving as a competitive enterprise: Men will donate four times more money to an attractive female fundraiser if they feel like they are in competition with another male, which evolutionary psychologists contend is a subconscious sexual mandate based on biology.