At one time,  J. Craig Venter, Ph.D.,  was a maverick outsider, determined to beat Big Science to the human genome and at a lot less cost.  Now he is the ultimate insider, giving a plenary talk at the most recent American Chemical Society meeting.

Venter 's talk described a fundamental shift in his field of genomics and its promise for producing synthetic life that could help provide 21st century society with new fuels, medicines, food and nutritional products, supplies of clean water and other resources. He isn't wrong all that often so his words have weight. He went head-to-head with government-controlled science on decoding the human genome and it only ended when the teams declared a tie, with simultaneous publications in 2001. 

Now, he notes that scientists are using decades of knowledge garnered from sequencing or "reading" the genetic codes of thousands of living things to now start writing new volumes in the library of life. 

"Genomics is a rapidly evolving field and my teams have been leading the way from reading the genetic code — deciphering the sequences of genes in microbes, humans, plants and other organisms — to writing code and constructing synthetic cells for a variety of uses. We can now construct fully synthetic bacterial cells that have the potential to more efficiently and economically produce vaccines, pharmaceuticals, biofuels, food and other products."

He's talking about synthetic biology, which draws heavily on chemistry, metabolic engineering, genomics and other scientific disciplines. Synthetic biology emerged from genetic engineering, the now-routine practice of inserting one or two new genes into a crop plant or bacterium. The genes can make tomatoes, for instance, ripen without softening or goad bacteria to produce human insulin for treating diabetes. Synthetic biology, however, involves rearranging genes on a much broader scale — that of a genome, which is an organism's entire genetic code — to reprogram entire organisms and even design new organisms.

The J. Craig Venter Institute (JCVI announced in 2010 that they had constructed the world's first completely synthetic bacterial cell. Using computer-designed genes made on synthesizer machines from four bottles of chemicals, the scientists arranged those genes into a package, a synthetic chromosome. When inserted into a bacterial cell, the chromosome booted up the cell and was capable of dividing and reproducing.

In the ACS talk, Venter described progress on major projects, including developing new synthetic cells and engineering genomes to produce biofuels, vaccines, clean water, food and other products. That work is ongoing at both JCVI and at his company, Synthetic Genomics Inc. (SGI). A project at SGI for instance, aims to engineer algae cells to capture carbon dioxide and use it as a raw material for producing new fuels. Another group uses synthetic genomic advances with the goal of making influenza vaccines in hours rather than months to better respond to sudden mutations in those viruses.

Venter also described his work in sequencing the first draft human genome in 2001 while he and his team were at Celera Genomics, as well as the work on his complete diploid genome published in 2007 by scientists at JCVI, along with collaborators at The Hospital for Sick Children in Toronto and the University of California, San Diego. In addition to continued analysis of Venter's genome, he and his team are also studying the human microbiome, the billions of bacteria that live in and on people, and how these microbes impact health and disease.

While technology is rapidly changing, making human genome sequencing more and more accessible, the accuracy of these next generation machines remain a challenge. Thus, Venter believes it may be years before such full-genome sequences become accurate enough to find a place in routine medical care.

Source: J. Craig Venter, Ph.D., "From Reading to Writing the Genetic Code", 243rd National Meeting&Exposition of the American Chemical Society (ACS) in San Diego