Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
BPA - Bisphenol A - has been besieged by so much negative public relations that it is almost indefensible. Like smoking, people are going to blame it for everything they can. But research is sometimes about inconvenient truths and so a three-year study using more than 2,800 mice that was not able to replicate a series of previous studies finding harm has to be mentioned. The authors are quick to note they are not declaring BPA safe, rather just that they could not reproduce the developmental effects of BPA in babies in the womb - which used to be the definition of safe. The estrogenic compound found in plants, genistein, was also studied and results of other studies could not be reproduced.
Though you can't put science data to a vote, the policies based on science are for the public to decide.
Until a global policy is in place, scientists and organizations can easily circumvent international laws regarding geo-engineering by getting domestic approval, as we saw with LOHAFEX and environmental activist Russ George dumping iron in the ocean to create algal blooms, in defiance of treaties prohibiting it.
A radiotracer has shown that researchers who used electricity on certain regions in the brain of a patient with chronic, severe facial pain led to release of an opiate-like substance that's considered one of the body's most powerful painkillers.
In their current study, researcher intravenously administered a radiotracer that reached important brain areas in a patient with trigeminal neuropathic pain (TNP), a type of chronic, severe facial pain. They applied the electrodes and electrically stimulated the skull right above the motor cortex of the patient for 20 minutes during a PET scan (positron emission tomography). The stimulation is called transcranial direct current stimulation (tDCS).
Reconstructions of atmospheric CO2 concentrations and sea level over the past 40 million years show that greenhouse gas concentrations similar to the present (nearly 400 parts per million) were associated with sea levels at least nine meters above current levels.
They determined the 'natural equilibrium' sea level for CO2 concentrations ranging between ice-age values of 180 parts per million and ice-free values of more than 1,000 parts per million. Of course, it takes centuries for equilibrium to be reached so they don't try to predict any sea level value for the coming century but it can help illustrate what sea level might be expected if climate were stabilized at a certain CO2 level for several centuries.
A team of archaeologists has made discoveries of extensive water management and agricultural production in and around the ancient desert city of Petra, located in present-day Jordan.
Successful terrace farming of wheat, grapes and possibly olives resulted in a vast, green, agricultural "suburb" to Petra in an otherwise inhospitable, arid landscape. This terrace farming remained extensive through the third century and surface finds plus comparative data shows this type of farming continued in some extent until around the end of the first millennium, between 800 and 1000 A.D.
Galactan is a polymer of galactose, a six-carbon sugar that can be readily fermented by yeast into ethanol and is a target of interest for those researching advanced biofuels produced from cellulosic biomass.Galactans are polysaccharide components of pectin, the sticky sugar substance that binds together the individual cells in plant cell walls (and is used to make delicious jellies and jams). The β-1,4-galactan component of pectin is especially abundant in the “tension wood” that forms in cell walls in response to mechanical stress from wind or snowfall. An international collaboration has identified the first enzyme capable of substantially boosting the amount of galactan in plant cell walls.
Sex is not just an activity confined to higher animals such as mammals and not just for reproduction. The changes in offspring that result during reproduction are integral to the continuing adaptation and evolution of millions of species of plants, fungi and other organisms throughout the food chain.
Successful solo rock/pop stars are around twice as likely to die early as those in equally famous bands, indicates fascinating research you can read before you over-indulge on New Year's Eve. Though you could have read this same paper on New Year's Eve in 2007, in a different journal, just covering a slightly shorter period. Maybe researchers had a 2012 publish or perish deadline.
A combination of robotic devices that disperse a time-honored bleaching agent into the air and then detoxify the disinfecting chemical are highly effective at killing and preventing the spread of multiple-drug-resistant bacteria - MRSA and so-called superbugs.
These hydrogen peroxide vaporizers were first deployed in several Singapore hospitals during the 2002 outbreak of severe acute respiratory syndrome, or SARS, and later stocked by several U.S. government agencies in case of an anthrax attack
Researchers have identified a mechanism by which the bacterium Staphylococcus aureus (S. aureus) colonizes our nasal passages, showing for the first time that a protein located on the bacterial surface called clumping factor B (ClfB) has high affinity for the skin protein loricrin.
Researchers in Spain have mixed paper industry waste with ceramic material used in the construction industry and created a brick that has low thermal conductivity and so is a good insulator.
What's the catch? Its mechanical resistance still requires improvement.
The scientists collected cellulous waste from a paper factory (recycled) along with sludge from the purification of its waste water. In their laboratory they then mixed this material with clay used in construction and passed the mixture through a pressure and extrusion machine to obtain bricks.
Researchers have described a new selective target in muscle regeneration. This is the association of alpha-enolase protein and plasmin, findings which could be used to develop new treatments to regenerate muscular injuries or dystrophies.