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First Goat Genome Facilitates De Novo Assembly Of Large Genomes

First Goat Genome Facilitates De Novo Assembly Of Large Genomes

Researchers have completed the first genome sequence of domestic goat by integrating next-generation sequencing (NGS) and whole-genome mapping (WGM) technologies. The goat genome is the first reference genome for small ruminant animals and may help to advance the understanding of distinct ruminants' genomic features from non-ruminant species.
This work also yields a valuable experience for facilitating the de novo assemblies of large, complex genomes in the future. 

Newborn Baby Screening For Fragile X Syndrome FMR1 Gene Mutations

Newborn Baby Screening For Fragile X Syndrome FMR1 Gene Mutations

A study into newborn screening for fragile X syndrome (FXS) demonstrates that testing for mutations in the gene FMR1 can be done on a large scale, according to a paper published in Genome Medicine which shows that the number of carrier babies who carry the form of the gene known as the "premutation" is higher than previously estimated.
Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability and autism, or autism spectrum disorder, and is caused by mutations in the gene FMR1.
The mutation which causes FXS is not actually in the gene but is due to the addition of extra CGG repeats in the promoter region that controls whether the gene is switched on or off.

Branch Retinal Vein Occlusion - Cause Of Widespread Eye Disease Identified

Branch Retinal Vein Occlusion - Cause Of Widespread Eye Disease Identified

Branch retinal vein occlusion – blockage of the blood vessels that channel blood from the retina – is a common eye disease. A type of blood clot in the eye, the disease causes reduced vision, and people with the disease also typically have an increased risk of hypertension, diabetes and other serious conditions.
 Mette Bertelsen from the University of Copenhagen and colleagues photographically verified the diagnosis of branch retinal vein occlusion in 1168 people.

Doing The Math For How Songbirds Learn To Sing

Doing The Math For How Songbirds Learn To Sing

Scientists studying how songbirds stay on key have developed a statistical explanation for why some things are harder for the brain to learn than others.
"We've built the first mathematical model that uses a bird's previous sensorimotor experience to predict its ability to learn," says Emory biologist Samuel Sober. "We hope it will help us understand the math of learning in other species, including humans."
Sober conducted the research with physiologist Michael Brainard of the University of California, San Francisco.
Their results, showing that adult birds correct small errors in their songs more rapidly and robustly than large errors, were published in the Proceedings of the National Academy of Sciences (PNAS).

NGC 5189: Hubble's Cosmic Tree Ornament Gift To You

NGC 5189: Hubble's Cosmic Tree Ornament Gift To You

Nearby planetary nebula NGC 5189 and its bright gaseous nebula resembles a holiday ornament with a glowing ribbon - so it is perfect for a new Hubble image during the Christmas season. Planetary nebulae represent the final brief stage in the life of a medium-sized star. While consuming the last of the fuel in its core, the dying star expels a large portion of its outer envelope and this material then becomes heated by the radiation from the stellar remnant and radiates, producing glowing clouds of gas that can show complex structures, as the ejection of mass from the star is uneven in both time and direction.

A Midwestern Snowstorm In Infrared Light

A Midwestern Snowstorm In Infrared Light

Low pressure areas that dropped more than a foot of snow in some Midwestern states have prompted many warnings and weather advisories. Satellite data recently got a look at a major snowstorm.
On Dec. 21st, 2012, at 0729 UTC (2:29 a.m. EST), the Atmospheric Infrared Sounder (AIRS) instrument that flies aboard NASA's Aqua satellite captured an infrared image of the massive low pressure area that caused a major snowstorm in the Midwest and beyond. 

Brain Imaging Shows Cannabis Only Brings Subjective Pain Relief

Brain Imaging Shows Cannabis Only Brings Subjective Pain Relief

Brain imaging shows us what is happening during events and stimuli but it can't tell us much about how or why. Regardless, conclusion are often drawn and the poles of cultural debates are always jumping on the latest study to affirm their beliefs.
No one will be satisfied with a new University of Oxford study which concluded that the pain relief offered by cannabis is all subjective. The researchers found that an oral tablet of THC, the psychoactive ingredient in cannabis, tended to make the experience of pain more bearable, rather than actually reduce the intensity of the pain. MRI brain imaging showed reduced activity in key areas of the brain that substantiated the pain relief the study participants experienced. 

Black Piranha Vs Megapiranha For Most Powerful Bite Ever

Black Piranha Vs Megapiranha For Most Powerful Bite Ever

Taking body size into account, the black piranha and the extinct megapiranha have the most powerful bites of carnivorous fishes throughout known history.
It's no surprise they were both in the finals: The piranhas' specialized jaw morphology allows them to attack and bite chunks out of much larger prey and their aggressive nature, relatively small size and accessible populations make them a suitable group of predatory vertebrates in which to study the evolution of extreme biting capabilities. Even at their small body sizes, diet studies indicate that piranhas will attack and bite chunks of bony fins and flesh from prey many times larger than themselves.

P53: The Genetic Link Between Flying, Cancer Resistance And Longevity

P53: The Genetic Link Between Flying, Cancer Resistance And Longevity

The Australian mega bat and a Chinese micro bat may provide clues to the future treatment and prevention of infectious diseases and cancer in people, say researchers. 
These bats evolved flight, resistance to viruses and the ability to live relatively long time, say the team sequencing the genomes of the two bat species. They then compared the bat genomes to the genomes of eight other mammals, including humans, to find similarities and differences.
 

HoxD13: Researchers Engineer Zebrafish To Grow A Leg

HoxD13: Researchers Engineer Zebrafish To Grow A Leg

Neil Shubin alert: Researchers have found evidence that the development of hands and feet occurred through the gain of new DNA elements that activate particular genes - and they used a zebrafish to show it. 
The transition from water to land was obviously a major event in the history of vertebrate
life. In order to understand how fins may have evolved into limbs, researchers introduced extra Hoxd13, a gene known to play a role in distinguishing body parts, at the tip of a zebrafish embryo's fin. This led to the generation of new cartilage tissue and the reduction of fin tissue—changes that are similar to key aspects of land-animal limb development. 

Clays Force A Rethink Of The Water History Of Mars

Clays Force A Rethink Of The Water History Of Mars

A new study indicates that clay minerals, formed when water is present for long periods of time, cover a larger portion of Mars than previously thought. Clays were in some of the rocks studied by Opportunity when it landed at Eagle crater in 2004. The rover only detected acidic sulfates and has since driven about 22 miles to Endeavour Crater and clay minerals have been detected using a spectroscopic analysis from the Mars Reconnaissance Orbiter. The clays also exist in the Meridiani plains that Opportunity rolled over as it trekked toward its current position.