Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
AMSTERDAM, June 13, 2012 -- Elsevier has added a new enhancement to SciVal Strata, a web-based performance evaluation tool that allows users to conduct highly customized performance assessments of research teams and individual researchers. The new functionality provides the capacity for objective assessment of a specific selection of a researcher's work in addition to their complete publication output. This option is critical when selecting the most impactful papers to be submitted for various government or institutional assessments. In addition the enhanced functionality will prove useful to individuals applying for grants and showing funders the impact of the research they supported.
MELBOURNE, Australia, June 13 -- In what is being billed as the world's largest international study of online consumer behavior, involving over 36,000 users (though that sounds low - we could easily get more than 36,000 respondents to a survey today), differences between online behavior cultures were found, including the secret to success - which appears to be simplicity.
The Webreep online consumer survey analyzed consumer behavior on the internet between May 2011 and May 2012. Participants were distributed across 7 regions, including France, Germany, Spain, Australia, China, and Russia.
The study found Americans are the most trusting, 20% more than Europeans, Chinese (23%), and Russians (33%).
Oxitec's novel genetic fluorescent marking technology can substantially improve control of the cotton pest moth, pink bollworm, according to findings of a new study.
A new study has found that individuals taking cholesterol-lowering statin drugs are more likely than non-users to experience decreased energy, fatigue upon exertion, or both. The researchers suggest that these findings should be taken into account by doctors when weighing risk versus benefit in prescribing statins. Statins are among the most widely used prescription drugs on the market and therefore increased attention has focused on statins' side effects, particularly their effect on exercise. While some patients have reported fatigue or exercise intolerance when placed on statins, randomized trials had not previously addressed the occurrence of fatigue-with-exertion or impaired energy in patients on statins relative to placebo.
A team of Georgia Tech Sonification Lab (SonLab) students and psychologists have converted numerical data of celestial bodies into music.The band Echo Movement wanted something distinct so they asked Georgia Tech for help. Rhythms, pitches and tempos needed to evoke a "heavenly" sound so the musicians and students went to work with existing data gathered by NASA's Kepler telescope. They began with a binary star, Kepler 4665989, which had brightness levels recorded for more than a year. The star dimmed and brightened each time its companion star crossed its path, providing varying brightness measurements.
A few years ago, Netherlands Institute of Ecology (NIOO-KNAW) researchers discovered that soil-dwelling and above-ground insects are able to communicate with each other using the ragwort plant as a kind of telephone. Insects eating plant roots change the chemical composition of the leaves, causing the plant to release volatile signals into the air. This can convince aboveground insects to select another food plant in order to avoid competition and to escape from poisonous defense compounds in the plant. Apparently the communication doesn't stop there.
At Science 2.0, we often joke that biologist Neil Shubin from the University of Chicago can make anything about fish. That's because we've never heard him not able to make anything about fish. His books, talks and research methods show great examples of multidisciplinary research - biology tells us what should have existed, geology tells us the conditions where something might be found and paleontology finds it.A spine with multiple segments is a feature of land-dwelling animals but the discovery of the same anatomical feature in a 345-million-year-old eel suggests that this complex anatomy arose separately from, and perhaps before, the first species to walk on land.
Results from the first feasibility study of an advanced first-generation artificial pancreas system were presented at the American Diabetes Association Meeting in Philadelphia and findings from the study indicated that the Hypoglycemia-Hyperglycemia Minimizer (HHM) System was able to automatically predict a rise and fall in blood glucose and correspondingly increase and/or decrease insulin delivery safely. Currently the most effective method of measuring blood glucose levels is with a blood glucose meter from Dexcom or other suppliers.
The HHM System included a continuous, subcutaneous insulin pump, a continuous glucose monitor (CGM) and special software used to predict changes in blood glucose.
New chemical compounds that can make key modifications to common sugar molecules - glycans - which are found on the surface of all cells in our body are new tools for investigating treatments for chronic inflammation, autoimmune diseases, cancer metastasis and related conditions.A new study describes compounds that selectively block the attachment to the cell of two types of sugar building blocks, sialic acid and fucose, which are found at the tips of cell surface glycans and can be critical to cell function.
Around 100,000 years ago, human evolution was in a rut, modern human ancestors consisted of 5-10,000 individuals living in Africa.Yet modern humans somehow emerged from this population bottleneck, expanding dramatically in both number and range, and replacing all other co-existing evolutionary cousins, like Neanderthals. What caused this bottleneck in the first place? Answers range from gene mutations to cultural developments like language to climate-altering events, like a massive volcanic eruption. Maybe there is another possible factor: infectious disease.
Researchers announced the discovery of Afrasia djijidae, a new early anthropoid fossil. The 37-million-year-old Afrasia djijidae resembles another early anthropoid, Afrotarsius libycus, recently discovered at a site of similar age in the Sahara Desert of Libya. That close similarity between Afrasia and Afrotarsius indicates that early anthropoids colonized Africa only shortly before the time when these animals lived. The colonization of Africa by early anthropoids was a pivotal step in primate and human evolution, because it set the stage for the later evolution of more advanced apes and humans there.
There was a time when giant insects ruled the skies and it corresponded to high oxygen levels.After the evolution of birds, about 150 million years ago, insects got smaller - despite rising oxygen levels. What gives?Insects reached their biggest sizes about 300 million years ago during the late Carboniferous and early Permian periods. This was the reign of the predatory griffinflies, giant dragonfly-like insects with wingspans of up to 28 inches - creepy. The leading theory attributed their large size to high oxygen concentrations in the atmosphere (over 30 percent, compared to 21 percent today), which allowed giant insects to get enough oxygen through the tiny breathing tubes that insects use instead of lungs.