A multi-institutional team of researchers has reported the sequences for all of the 99 known strains of cold virus, nature's most ubiquitous human pathogen. The feat exposes, in precise detail, all of the molecular features of the many variations of the virus responsible for the common cold, the inescapable ailment that makes us all sneeze, cough and sniffle with regularity. Conducted by teams at the University of Maryland School of Medicine, the University of Wisconsin-Madison and the J. Craig Venter Institute, the work to sequence and analyze the cold virus genomes lays a foundation for understanding the virus, its evolution and three-dimensional structure and, most importantly, for exposing vulnerabilities that could lead to the first effective cold remedies.