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Why Do Some Obese People Stay Metabolically Healthy?

Why Do Some Obese People Stay Metabolically Healthy?

Some obese individuals do not appear to have an increased risk for heart disease, while some normal-weight individuals experience a cluster of heart risks, according to two reports in the August 11/25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
"The prevalence of obesity is increasing worldwide, and this epidemic is accompanied by a high incidence of type 2 diabetes mellitus and cardiovascular disease," the authors write as background information in one of the articles. Research indicates that in addition to overall obesity, the way body fat is distributed may influence risk for heart disease and diabetes. For instance, individuals with fat within the abdominal cavity—estimated by measuring waist size—appear to be at higher risk for insulin resistance (a pre-diabetic condition that occurs when the body fails to respond to the hormone insulin) and for having an unhealthy cardiovascular risk profile.

Can't See?  Maybe Your Hearing Is Going Bad

Can't See? Maybe Your Hearing Is Going Bad

The traditional view of individual brain areas involved in perception of different sensory stimuli, with one brain region involved in hearing and another involved in seeing, has been thrown into doubt in recent years.
A new study published in BMC Neuroscience shows that, in monkeys, the region involved in hearing can directly improve perception in the visual region, without the involvement of other structures to integrate the senses.

Zippori National Park Reveals Ancient Roman Temple

Zippori National Park Reveals Ancient Roman Temple

Ruins of a Roman temple from the second century CE have recently been unearthed in the Zippori National Park in Israel. Above the temple are foundations of a church from the Byzantine period.
The discovery indicated that Zippori, the Jewish capital of the Galilee during the Roman period, had a significant pagan population which built a temple in the heart of the city center. The central location of the temple which is positioned within a walled courtyard and its architectural relation to the surrounding buildings enhance our knowledge regarding the planning of Zippori in the Roman era.

MicroRNA miR-126 Controls Blood Vessel Development

MicroRNA miR-126 Controls Blood Vessel Development

Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs.
The research, published in the latest issue of Developmental Cell, may offer clues to potential therapeutic targets for a wide variety of diseases, such as heart disease or cancer, that are impacted by or affect the vascular system.
Researchers in laboratory of GICD Director Deepak Srivastava, MD, found that microRNA (miR-126), a tiny RNA molecule, is intimately involved in the response of blood vessels to angiogenic signals. Angiogenesis, the process of vascular development, is a tightly regulated and well-studied process.A cascade of genes orchestrate a series of events leading to formation of blood vessels in an embryo.

Hox, Senseless And The Molecular Switch That Helps Decide Cell Type

Hox, Senseless And The Molecular Switch That Helps Decide Cell Type

Researchers have discovered a central molecular switch in fruit fly embryos that opens new avenues for studying the causes of birth defects and cancer in humans. Writing about their study in the Aug. 12 Developmental Cell, scientists at Cincinnati Children's Hospital Medical Center determined the switch to be a main tuning mechanism for instructing cells whether to form sensory nerves or blood cells in different parts of the body.

Flexible Nanoantennas Put Us On The Road To Affordable Solar Power

Flexible Nanoantennas Put Us On The Road To Affordable Solar Power

Researchers at the U.S. Department of Energy's Idaho National Laboratory say they have devised an inexpensive way to produce plastic sheets containing billions of nanoantennas that collect heat energy generated by the sun and other sources.
They say this technology is the first step toward a solar energy collector that could be mass-produced on flexible materials.
Traditional solar cells rely on a chemical reaction that only works for up to 20 percent of the visible light they collect. Scientists have developed more complex solar cells with higher efficiency, but these models are too expensive for widespread use.

'Sleep On It' Debunked - Unconscious Thought No Better Than Thinking Through Tough Problems

'Sleep On It' Debunked - Unconscious Thought No Better Than Thinking Through Tough Problems

Neither snap judgements nor sleeping on a problem are any better than conscious thinking for making complex decisions, according to new research that the researchers say debunks a controversial 2006 research result asserting that unconscious thought is superior for complex decisions, such as buying a house or car.
If anything, the new study suggests that conscious thought leads to better choices.
Since its publication two years ago by a Dutch research team in the journal Science, the earlier finding had been used to encourage decision-makers to make "snap" decisions (for example, in the best-selling book Blink, by Malcolm Gladwell) or to leave complex choices to the powers of unconscious thought ("Sleep on it", Dijksterhuis et al., Science, 2006).

Invisibility Cloak Gets A Nanomaterial Boost

Invisibility Cloak Gets A Nanomaterial Boost

Scientists at the University of California, Berkeley, have for the first time engineered 3-D materials that can reverse the natural direction of visible and near-infrared light, a development that could help form the basis for higher resolution optical imaging, nanocircuits for high-powered computers, and, to the delight of science-fiction and fantasy buffs, cloaking devices that could render objects invisible to the human eye.
Two breakthroughs in the development of metamaterials - composite materials with extraordinary capabilities to bend electromagnetic waves - are reported separately this week in the Aug. 13 advanced online issue of Nature, and in the Aug. 15 issue of Science.

Saving Brains - Fetal Alcohol Syndrome Discovery In Sheep Could Help Humans Soon

Saving Brains - Fetal Alcohol Syndrome Discovery In Sheep Could Help Humans Soon

In a study on fetal alcohol syndrome, researchers were able to prevent the damage that alcohol causes to cells in a key area of the fetal brain by blocking acid sensitive potassium channels and preventing the acidic environment that alcohol produces. The cerebellum, the portion of the brain that is responsible for balance and muscle coordination, is particularly vulnerable to injury from alcohol during development.
The researchers also found that although alcohol lowers the amount of oxygen in the blood of the mother, it is not the lack of oxygen that damages the fetal cerebellum, but the drop in pH.

LAMA5 Gene Variations Affect Obesity In Women Of African And European Descent, Says Study

LAMA5 Gene Variations Affect Obesity In Women Of African And European Descent, Says Study

A study of 228 women has revealed genetic variants responsible for body shape, according to research published in BMC Genetics.
Based on work in the fruit fly Drosophila melanogaster, the study identifies natural variation in the human LAMA5 gene as a key determinant of weight.
As the prevalence of obesity and related health problems continues to increase worldwide, there is considerable effort being devoted to identify genetic mechanisms that control fat storage. Maria De Luca led a team from the University of Alabama at Birmingham, USA, who identified candidate genes using different strains of Drosophila.

Prevotella histicola - New Species Of Bacteria Found In The Human Mouth

Prevotella histicola - New Species Of Bacteria Found In The Human Mouth

Scientists have discovered a new species of bacteria in the mouth. The finding could help scientists to understand tooth decay and gum disease and may lead to better treatments, according to research published in the August issue of the International Journal of Systematic and Evolutionary Microbiology.
"The healthy human mouth is home to a tremendous variety of microbes including viruses, fungi, protozoa and bacteria," said Professor William Wade from King's College London Dental Institute. "The bacteria are the most numerous: there are 100 million in every millilitre of saliva and more than 600 different species in the mouth. Around half of these have yet to be named and we are trying to describe and name the new species."

Sustainable Development Is a Mirage, Argues Environmental Author

Sustainable Development Is a Mirage, Argues Environmental Author

Sustainable development thinking got environmental issues onto the agenda but it may now be stopping us from taking serious action on climate change and other crucial planetary issues, argues John Foster, a freelance writer and teacher and honorary Research Fellow in Philosophy at Lancaster University, UK in his new book "The Sustainability Mirage: Illusion and Reality in the Coming War on Climate Change."
Sustainable development's attempted deal between present and future will always collapse under the pressure of 'now' because the needs of the present always win out, he says. Inevitably, this means movable targets and action that will always fall short of what we need. Ultimately, sustainable development is the pursuit of a mirage, the politics of never getting there.