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Research: "Printing" Organs Could Lead To Better Drug Trials And Faster Transplants

Research: "Printing" Organs Could Lead To Better Drug Trials And Faster Transplants

For the past four years, Gabor Forgacs, Professor of Physics at University of Missouri-Columbia, has been working to refine the process of “printing” tissue structures of complex shape with the aim of eventually building human organs. In a new study, the research team led by Forgacs determined that the process of building such structures by printing does not harm the properties of the composing cells and the process mimics the naturally occurring biological assembly of living tissues.
The reason; each year, pharmaceutical companies invest millions of dollars to test drugs, many of which will never reach the market because of side effects found only during human clinical trials. At the same time, the number of patients waiting for organ transplants continues to increase.

Corticosterone, Genetics And The Addiction Of Nicotine

Corticosterone, Genetics And The Addiction Of Nicotine

Individual brain chemistry and genes could be key to understanding why some people become addicted to nicotine and why the chemical compound's effects appear to diminish at night, University of Colorado at Boulder researchers say.
"The depth of a person's addiction to nicotine appears to depend on his or her unique internal chemistry and genetic make-up," said lead author Jerry Stitzel, an assistant professor in CU-Boulder's department of integrative physiology and researcher with CU-Boulder's Institute for Behavioral Genetics.
He and his team set out to evaluate the effects of nicotine over the course of a day by examining mice that could make and "recognize" melatonin, a powerful hormone and antioxidant, and others that could not.

Green Agriculture Productivity Boosts In Africa

Green Agriculture Productivity Boosts In Africa

It doesn't always seem that 'green' agriculture and the productivity improvements necessary to feed developing countries go hand-in-hand, but a group of speakers including Dr.

Avoiding More 'Big Brother' In England

Avoiding More 'Big Brother' In England

The eeriest thing about visiting London is knowing you are being photographed 300 times per day yet still have a higher chance than all civilized countries except fellow UK member Scotland of being a victim of violent crime.

Monkeys Rationalize Their Decisions Too

Monkeys Rationalize Their Decisions Too

Like adults, children and monkeys rationalize their decisions following a tough choice, Yale University researchers report in Psychological Science.
The tendency to rationalize after, for instance, deciding what job to take, which car to buy, or who to marry, is a way to resolve “cognitive dissonance”—a psychological state in which an individual’s beliefs, attitudes, and behaviors are at odds, said Louisa Egan, the lead author and doctoral student of psychology.
The dissonance—the anxiety over an appealing road not taken—is uncomfortable and people are driven to resolve these feelings by rationalizing their choices, she said. One way to do this is by downgrading, or denigrating, the option that wasn’t chosen.

Species Extinction Could Reduce Productivity Of Plants By Half

Species Extinction Could Reduce Productivity Of Plants By Half

An international team of scientists has published a new analysis showing that as plant species around the world go extinct, natural habitats become less productive and contain fewer total plants –– a situation that could ultimately compromise important benefits that humans get from nature.
“The process by which plants grow and produce more plant biomass is one of the most fundamental biological processes on the planet,” said Bradley Cardinale, lead author of the paper and assistant professor of biology at the University of California, Santa Barbara.

20 Year Study: Exercise Keeps Weight Gain Down

20 Year Study: Exercise Keeps Weight Gain Down

A consistently high level of physical activity from young adulthood into middle age increases the odds of maintaining a stable weight and lessens the amount of weight gained over time, according to a new analysis from Northwestern University's Feinberg School of Medicine.
People who reported at least 30 minutes of vigorous activity a day such as jogging, bicycling or swimming were more than twice as likely to maintain a stable Body Mass Index (BMI) over 20 years. BMI is a measure of body fat based on height and weight. But even highly active people who gained weight, gained 14 pounds less over 20 years than those with consistently low activity.

Breastfeeding Makes Kids Smarter; If They Have The Right FADS2 Gene Variant

Breastfeeding Makes Kids Smarter; If They Have The Right FADS2 Gene Variant

Breastfeeding boosts infants’ IQs, but only if the babies have a genetic variant that enhances their metabolism of breast milk, according to a report in Proceedings of the National Academy of Sciences.
“It is this genetic variant in FADS2, a gene involved in the control of fatty acid pathways, that may help the children make better use of the breast milk and promote the brain development that is associated with a higher IQ score,” said Julia Kim-Cohen, assistant professor of psychology and a member of the research team.
“Children who do not carry the ‘helpful’ genetic variant have normal average IQ scores,” Kim-Cohen said. “Being breastfed for them is not associated with an IQ advantage.”

Zanzibar Malaria Success:  Child Deaths Reduced 75%

Zanzibar Malaria Success: Child Deaths Reduced 75%

Malaria kills about one million people every year and most are young children living in Africa. The parasite responsible is transmitted to people when they are bitten (usually at night) by an infected mosquito. The World Health Organization now recommends a new form of treatment known as artemisinin-based combination therapies (ACTs), which include the drug artemisinin – obtained from the sweet wormwood plant. ITNs (long-lasting insecticidal nets) are also strongly promoted.
Research in Zanzibar,Tanzania, where people with malaria have had free access to ACT since late 2003 and children under five years old and pregnant women have been given free ITNs since early 2006, has found a remarkable fall in the number of children dying from malaria.

APOE4 Implicated In Alzheimer's Also Means Reduced Cognitive Function In Kids

APOE4 Implicated In Alzheimer's Also Means Reduced Cognitive Function In Kids

Children who possess a gene known to increase the risk of Alzheimer's disease already show signs of reduced cognitive function, an Oregon Health & Science University study has found.
Scientists in the OHSU School of Medicine discovered that 7- to 10-year-olds with a member of a family of genes implicated in development, nerve cell regeneration and neuroprotection display reduced spatial learning and memory, associated with later-life cognitive impairments.
Results of the study, presented today at Neuroscience 2007, the 37th annual meeting of the Society for Neuroscience in San Diego, suggest that changes predisposing a person to Alzheimer's and other forms of dementia might occur much sooner in the brain than previously thought.

Stellar Occultation: Stargazing That's More Than Just Romance

Stellar Occultation: Stargazing That's More Than Just Romance

When the stars are shining above the atmosphere, they give off radiation across a wide spread of wavelengths. As Earth rotates, the star appears to sink down. When that happens, the atmosphere acts as a filter, blocking out certain wavelengths of the star’s radiation. While nice to see with your girlfriend, of importance to astronomers is that the blocked wavelengths are representative of the molecules and atoms in the planet’s atmosphere.
It's known as stellar occultation. Jean-Loup Bertaux, Service d'Aeronomie du CNRS, France was the first to suggest its use on an ESA mission. It works by watching stars from space, while they drop behind the atmosphere of a planet under investigation, before disappearing from view below the planet’s horizon.

Rheumatoid Arthritis Gene Identified

Rheumatoid Arthritis Gene Identified

University of Manchester researchers have identified a genetic variant in a region on chromosome 6 that is associated with rheumatoid arthritis (RA), the most common inflammatory arthritis affecting 387,000 people in the UK.
Professor Jane Worthington and her team at the Arthritis Research Campaign (arc) Epidemiology Unit at the University investigated 9 genetic regions identified earlier this year as potentially harbouring DNA variants determining susceptibility to rheumatoid arthritis. Association to one of the variants on chromosome 6 was unequivocally confirmed, reports this week’s Nature Genetics (4 November 2007).