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Who Am I? Early Family Experiences, Self-esteem Linked To Existential Crises

Who Am I? Early Family Experiences, Self-esteem Linked To Existential Crises

Although children can emerge from cold and neglectful family environments as adults with high self-esteem, a new University at Buffalo psychology paper suggests they may still be at a relative disadvantage in life, with a foggier sense of identity. Yet obviously adults with low self-esteem who grew up in the same type of negative environment have relatively high self-clarity, so what gives?

Guanabenz Blood Pressure Drug Protects Against MS Symptoms In Animal Models

Guanabenz Blood Pressure Drug Protects Against MS Symptoms In Animal Models

Guanabenz is an FDA-approved drug for high blood pressure but a new study also finds that it prevents myelin loss and alleviates clinical symptoms of multiple sclerosis (MS) in animal models. The drug appears to enhance an innate cellular mechanism that protects myelin-producing cells against inflammatory stress. Multiple sclerosis is characterized by an abnormal immune response that leads to inflammation in the brain and the destruction of myelin - a fatty sheath that protects and insulates nerve fibers. MS is thought to affect more than 2.3 million people worldwide and has no known cure.

Ganymede: Inferring An Underground Ocean On Jupiter's Largest Moon

Ganymede: Inferring An Underground Ocean On Jupiter's Largest Moon

Ganymede, Jupiter's largest moon, is thought to have once had more water than all the water on Earth's surface.But why? Ganymede is the largest moon in our solar system and the only moon with its own magnetic field. The magnetic field causes aurorae, which are ribbons of glowing, hot electrified gas, in regions circling the north and south poles of the moon. Because Ganymede is close to Jupiter, it is also embedded in Jupiter's magnetic field. When Jupiter's magnetic field changes, the aurorae on Ganymede also change, "rocking" back and forth so by watching the rocking motion of the two aurorae, scientists were able to determine that a large amount of saltwater exists beneath Ganymede's crust affecting its magnetic field.

Metastatic Melanoma: Anti-Nodal Antibodies Plus Dacarbazine Promising

Metastatic Melanoma: Anti-Nodal Antibodies Plus Dacarbazine Promising

Metastatic melanoma is the leading cause of skin cancer deaths in the United States because once has spread - metastasized - life expectancy for patients is dramatically shortened. Melanoma diagnosis and treatment has progressed a lot and the future looks even brighter but the current reference therapy for patients diagnosed with metastatic melanoma is Dacarbazine (DTIC), which is associated with relatively poor patient outcomes.

Cancer Drug Epothilone Causes Damaged Nerve Cells In Spinal Cord Injuries To Regrow

Cancer Drug Epothilone Causes Damaged Nerve Cells In Spinal Cord Injuries To Regrow

Damage to the spinal cord is often permanent because injured nerve cells fail to regenerate due to scar tissue of their long nerve fibers. Nerve cells are wire-like conductors that transmit and receive signals in the form of electrical impulses. This function can be impaired by accidents or disease. Whether or not the affected nerves can recover largely depends on their location: for instance nerve cells in the limbs, torso and nose can regenerate to some degree and regain some or all of their function. 

CRISPR/Cas9 Labeling System Makes A GPS For The Genome

CRISPR/Cas9 Labeling System Makes A GPS For The Genome

A new app for finding and mapping chromosomal loci uses multicolored versions of CRISPR/Cas9. The labeling system, developed by  the University of Massachusetts Medical School, could be a key to understanding the spatial and temporal regulation of gene expression by allowing researchers to measure the precise linear distance between two known points on different chromosomes or two locations on the same chromosome in live human cells. 

High Testosterone, Low Estrogen Linked To Male Heart Disease Risk

High Testosterone, Low Estrogen Linked To Male Heart Disease Risk

Why men have more heart disease than premenopausal women has been unclear, but a new study shows that the sex hormones testosterone and estrogen alter cardiovascular risk factors in a way that raises a man's risk of heart disease. Results of the study will be presented Saturday at the Endocrine Society's 97th annual meeting in San Diego.
Men have higher testosterone and lower estrogen levels than premenopausal women. Therefore, doctors have suspected that testosterone may promote cardiovascular disease or that estrogen may protect against it, or both, according to Elaine Yu, MD, MSc, the study's lead investigator and an assistant professor at Harvard Medical School, Boston.

How Much Vitamin E Is Enough? High Cholesterol May Make A Difference

How Much Vitamin E Is Enough? High Cholesterol May Make A Difference

A new study has found that high levels of blood lipids such as cholesterol and triglycerides can keep Vitamin E, an essential micronutrient, tied up in the blood stream, and prevent vitamin E from reaching the tissues that need it. That means measuring only blood levels may offer a distorted picture of whether or not a person has adequate amounts of the vitamin, and that past methods of estimating tissue levels are flawed.

Mind Reading: Brain Activity Of Taste Decoded

Mind Reading: Brain Activity Of Taste Decoded

A team of researchers can detect how taste is encoded in patterns of neural activity in the human brain. That means they can basically read your mind when it comes to food.Tastants in the mouth activate specific receptors on the tongue corresponding to each of the basic tastes: sweet, salty, sour, bitter, and savory (umami). The signal is then transduced further to the brain. How the peripheral signal is used by the central nervous system to encode taste quality is largely unknown.

Excess Nitrogen And Phosphorus Damages Streams In Ways Previously Unknown

Excess Nitrogen And Phosphorus Damages Streams In Ways Previously Unknown

An important food resource has been disappearing from streams without anyone noticing until now.
In a new study published March 6 in the journal Science, a team of researchers led by University of Georgia ecologists reports that nutrient pollution causes a significant loss of forest-derived carbon from stream ecosystems, reducing the ability of streams to support aquatic life.
The findings show that the in-stream residence time of carbon from leaves, twigs and other forest matter, which provide much of the energy that fuels stream food webs, is cut in half when moderate amounts of nitrogen and phosphorus are added to a stream.

Gut Microbial Mix Relates To Stages Of Blood Sugar Control

Gut Microbial Mix Relates To Stages Of Blood Sugar Control

The composition of intestinal bacteria and other micro-organisms--called the gut microbiota--changes over time in unhealthy ways in black men who are prediabetic, a new study finds. The results will be presented Friday at the Endocrine Society's 97th annual meeting in San Diego.