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Palbociclib, an investigational oral medication that works by blocking molecules responsible for cancer cell growth, is well tolerated and extends progression-free survival (PFS) in newly diagnosed, advanced breast cancer patients, including those whose disease has stopped responding to traditional endocrine treatments. Results of the phase II study, led by researchers in the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania , were published this month in Clinical Cancer Research. Earlier phase I results by researchers at Penn Medicine contributed to the development of palbociclib, which was recently approved by the U.S. Food and Drug Administration (FDA) for metastatic breast cancer patients just beginning to undergo endocrine therapy.

Case Western Reserve University dental researcher Pushpa Pandiyan has discovered a new way to model how infection-fighting T cells cause inflammation in mice.
The hope is that the discovery can lead to new therapies or drugs that jump-start weakened or poorly functioning immune systems, said Pandiyan, an assistant professor at Case Western Reserve School of Dental Medicine.
Pandiyan believes the process could lead to identifying and testing new drugs to replace antifungal medicines that have become ineffective as the fungi develop a resistance to them.
Pandiyan's findings are explained and demonstrated in the Journal of Visualized Experiments video and print article, "Th17 inflammation model of oropharyngeal candidiasis in immunodeficient mice."

Competition between doctors' offices, urgent care centers and retail medical clinics that cater to wealthy elites often leads to an increase in the number of antibiotic prescriptions written per person, finds a new analysis.The number of physicians per capita and the number of clinics are significant drivers of antibiotic prescription rate, they found, with the highest per capita rates of antibiotic prescriptions found in the southeastern U.S. and along the West and East coasts.
The team's comparative analysis of data for the years 2000 and 2010 were collected from the U.S. Census Bureau and the IMS Health Xponent database, which tracks prescriptions dispensed at the ZIP code level.
Notably high rates were found in Manhattan, southern Miami and Encino.

Researchers have linked a specific protein to the development of post-viral infection asthma, which is the first step in generating a novel type of asthma therapy designed to prevent development of post-viral asthma in young children.
Asthma is a chronic disease of the airways that affects more than 300 million people worldwide. It is the number one illness leading to school absences in children, and accounts for more than 1.8 million emergency room visits annually. There is no cure; all current therapies focus on providing symptomatic relief and reducing the number and severity of attacks.

A new paper says that breastfeeding and other factors influence a baby's immune system development and susceptibility to allergies and asthma by what's in their gut. The findings, from a series of studies further advance the so-called hygiene hypothesis theory that early childhood exposure to microorganisms affects the immune system's development and onset of allergies, says Christine Cole Johnson, Ph.D., MPH, chair of Henry Ford's Department of Public Health Sciences and principal research investigator.

Human pluripotent stem cells, which include both human embryonic stem cells(hESCs) and adult stem cells like induced pluripotent stem cells (iPSCs), need large numbers for transplantation into patients but the process of translating their potential into effective, real-world treatments involves deciphering and resolving a host of daunting complexities, according to a new study.The authors say they have definitively shown that the culture conditions in which stem cells are grown and mass-produced can affect their genetic stability.

Emulsifiers, which are added to processed foods to aid texture and extend shelf life, can alter the gut microbiota composition and localization to induce intestinal inflammation in mice that promotes the development of inflammatory bowel disease and metabolic syndrome, according to a new study.The team fed mice two commonly used emulsifiers, polysorbate 80 and carboxymethylcellulsose, at doses seeking to model the broad consumption of the numerous emulsifiers that are incorporated into almost all processed foods. They observed that emulsifier consumption changed the species composition of the gut microbiota and did so in a manner that made it more pro-inflammatory. 

Gender and personality matter in how people cope with physical and mental illness, according to a paper by a Washington State University scientist and colleagues at the University of the Thai Chamber of Commerce.
Men are less affected by a single-symptom illness than women, but are more affected when more than one symptom is present. The number of symptoms doesn't change how women are affected, according to Robert Rosenman, WSU professor in the Department of Economic Sciences. Rosenman worked with Dusanee Kesavayuth and Vasileios Zikos, both at UTCC in Bangkok, Thailand, on the study.

It's hard to hide from a bat: The camouflage and mimicry techniques that animals use to avoid becoming a meal aren't much use against a predator using echolocation. But a new study shows that moths can outsmart sonar with a flick of their long tails.
The study appearing in the Proceedings of the National Academy of Sciences shows luna moths spin their trailing hindtails as they fly, confusing the sonar cries bats use to detect prey and other objects.

What started as an evolutionary protection against starvation has become a biological "bad joke" for people who need to lose weight. The human body doesn't distinguish between dieting and possible starvation, so when there is a decrease in calories consumed, human metabolism increases its energy efficiency and weight loss is resisted.

Adolescent binge drinking has been linked to a host of problems, including worse school performance, risky sexual behaviors, illicit drugs, and a greater risk of suicide. Binge drinking may also be linked to problematic eating behavior, yet little research exists. A study of the relationship between binge drinking and eating problems among Russian adolescents has found that problematic eating behaviors and attitudes are commonplace, and that binge drinking is associated with more eating problems in girls than boys.
Results will be published in the March 2015 online-only issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.

Oats are often touted for lowering bad cholesterol,  improving the immune system, lowering blood pressure and, more recently, being gluten-free, but a new study finds that some oat-based breakfast cereals in the U.S. contain a mold-related toxin called ochratoxin A (OTA) that's been linked to kidney cancer in animal studies. Natural or not, they may need closer monitoring for potential mold contamination, warns a paper in the Journal of Agricultural and Food Chemistry.