Swedish clinicians recently reported the first live birth after uterus transplantation, which was followed by two more uneventful births and another pregnancy that is near term.

In a new Acta Obstetricia et Gynecologica Scandinavica commentary, one of the leaders behind these successes, Professor Mats Brannström, provides insights into how the Swedish uterus transplant project was initiated and its long research journey that spans over more than a decade. The first clinical uterus transplantation trial, which enrolled nine women, was initiated in early 2013 and is currently ongoing.

The preliminary results of the trial offer hope for women who lack a uterus--either from birth or due to a hysterectomy--or whose uterus is not functional.