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Knee Point Prediction And Battery Capacity Degradation

Knee Point Prediction And Battery Capacity Degradation

Electric cars and solar and wind energy alternative schemes have a few crippling limitations; low energy densities and unavailability when people need energy most. Batteries could help with that second one except current batteries are legacy technology that are held back by subsidies and mandates, not improved.

MicroRNA And The Microprocessor Inside You

MicroRNA And The Microprocessor Inside You

Since being discovered in 1993, microRNAs have gone on to win a Nobel Prize in Physiology or Medicine, thanks to private sector uptake with the COVID-19 vaccines that saved the world during the pandemic that emerged from Wuhan, China in early 2020.  Errors in the manufacture of over 1,000 microRNAs can put us at risk for developmental disorders, cancer, or neurodegenerative disease and a new study looks at a molecular machine called Microprocessor (MP), which trims longer molecules called primary microRNAs (pri-miRNAs) - without cutting other kinds of RNA that resemble pri-miRNAs.

What Next For Messenger RNA (mRNA)? Maybe Inhalable Vaccines

What Next For Messenger RNA (mRNA)? Maybe Inhalable Vaccines

No one likes getting a needle but most want a vaccine. A new paper shows progress for messenger RNA (mRNA), that can be sprayed and inhaled thanks to improved lipid-polymer nanoparticle technology for holding mRNA that is stable when nebulized and successfully delivers aerosols, liquid droplets, in mouse lungs.  A mouse study means this is only EXPLORATORY but the authors of the paper, including scientists from oRNA Therapeutics (RNA medicine) and Moderna (mRNA medicine), have filed for a patent while they get ready to see about human trials. 

Toward A Single Dose Smallpox And Mpox Vaccine With No Side Effects

Toward A Single Dose Smallpox And Mpox Vaccine With No Side Effects

Attorney Robert F. Kennedy Jr. and his US followers over the last 25 years have staunchly opposed vaccines, latching on to any claim that they cause autism or should be available for lawsuits even if they harm no one.They really won't like a new experimental vaccine for Smallpox and Monkeypox that avoids the side effects of a current live virus version while not needing two doses, as the replication-deficient virus version does. It uses the horsepox virus as a protective agent to confer the safety of a multi-dose vaccine in a single shot. 

Even After Getting Cancer, Quitting Cigarettes Leads To Greater Longevity

Even After Getting Cancer, Quitting Cigarettes Leads To Greater Longevity

Cigarettes are the top lifestyle risk factor for getting cancer, though alcohol and obesity have begun to close the gap as awareness of the risks of cigarettes, coupled with more nicotine smoking cessation and harm reduction tools, have caused cigarette use to decline.Even if you get cancer, quitting smoking improves outcomes. 

Non-Europeans Opt Out Of Genomic Databases, Leading To Lack Of Diversity

Non-Europeans Opt Out Of Genomic Databases, Leading To Lack Of Diversity

When Senator Elizabeth Warren had her claims of native ancestry debunked by DNA testing, it was a warning shot to everyone who identifies that way - don't take a test. Most native Americans had long said that anyway, they knew how biology worked better Washington DC staffers. After five generations there is a chance there will be no evidence of an ancestor so natives have long told their communities not to participate. If there are only a few hundred in a database, the database is meaningless and natives tribes can continue their 'we agree you are and you agree you are native' policy rather than having evidence.

Smarter Soybeans Mean Affordable Food In Poorer Regions

Smarter Soybeans Mean Affordable Food In Poorer Regions

It is easy for wealthy countries to spend $135 billion on an organic food process that uses higher quantities of older, more toxic pesticides at greater environmental strain, because it is a niche luxury item.In countries that are poor, which often means  outside natural breadbasket climates, the organic food process means cycles of famine and starvation. Science can help with that. Like humans, plants have a natural ability to adapt to unfavorable weather conditions but nature is only about individual survival, and humans need to think about yields if we're going to keep land use limited.

Shorter Course Of Post-Mastectomy Radiation With Breast Reconstruction Is Safe And Effective

Shorter Course Of Post-Mastectomy Radiation With Breast Reconstruction Is Safe And Effective

A multi-institutional study has found that a shorter course of post-mastectomy radiation, combined with breast reconstruction can time from 25 to 16 treatment sessions while remaining safe and effective.Breast cancer is the second most frequently diagnosed cancer for American women and nearly 40% have mastectomies. The majority who do undergo reconstructive breast surgery.

Bacterial Genes Can Be Genetic Shapeshifters

Bacterial Genes Can Be Genetic Shapeshifters

Prokaryotes, single-cell organisms such as bacteria, undergo inversions which cause a physical flip of a segment of DNA and change an organism’s genetic identity the way you might change a wig. They can occur within a single gene, in defiance of the more common 'one gene codes for one protein' standard.