Scientists have reported that an experimental vaccine targeting one of the most common genetic drivers of pancreatic cancer, called mutant KRAS, is safe and generated a durable immune responses aimed at preventing the cancer.
Currently, 1.5 billion people worldwide report chronic pain of varying degrees. Among all types of chronic pain, neuropathic pain stands out, with approximately 3-4.5% of the global population affected, and incidence rate increasing in line with increased age of the population. According to a recent estimate, the global pain management market is to reach US$60 Billion by 2015.[1]Convergence Pharmaceuticals Limited has started a Phase II proof of concept study with CNV2197944 in pain associated with post-herpetic neuralgia (PHN). Convergence is conducting the development of CNV2197944 on behalf of Calchan Ltd.
In a recent study, an area of the brain that initiates behavioral changes had greater activation in smokers who watched anti-smoking ads with strong arguments than ads with clever tricks like loud sounds and unexpected twists - and those smokers had significantly less nicotine metabolites in their urine when tested a month after viewing those ads.
Rainfall over the Hawaiian Islands has been declining since 1978.
Is the drying trend due to global warming? Yes, says a team of researchers who found that climate models don't have enough resolution to capture the diverse rainfall pattern over Hawaii, where dry and wet areas often lie only a mile or even less apart, and so devised a method called 'statistical downscaling.'
They first got a take on the effects of the general drying trend on local heavy-rain days by reanalyzing observations from 1978 to 2010 at 12 rain-gauge stations spread throughout the islands. Studying hundreds of weather patterns during such days, they identified the typical atmospheric circulation patterns in the North Pacific that favor heavy rains over Hawaii.
Bacterial vaginosis is a condition that occurs when the typical mix of microbes in the vagina is knocked off-kilter, sometimes resulting in a change in the consistency of vaginal fluids and an unpleasant odor. Bacterial vaginosis is diagnosed through examination of the vagina and tests of the vaginal fluids and then typically treated with antibiotics.
The condition affects as many as one in every three women, making it more common than yeast infections. But bacterial vaginosis often does not cause significant symptoms, leaving many women unaware they have it, but it has been linked to preterm birth and increased risk of sexually transmitted diseases. New research points to a common species of bacteria as an important contributor to bacterial vaginosis.
On March 24th, 1993, astronomers David Levy and Carolyn and Eugene M. Shoemaker discovered the first comet observed orbiting a planet rather than the Sun. Named Shoemaker-Levy 9 (SL9), it was found to be composed of 21 fragments. Soon after that, orbital studies showed that the comet had passed within Jupiter's Roche limit in July 1992. Inside this limit, the planet's tidal forces are strong enough to disintegrate a body held together by its own gravity, thus explaining SL9's fragmentation.
Results from "Aviator," AbbVie's phase IIb clinical trial of its investigational direct-acting antivirals (DAAs) for the treatment of hepatitis C virus (HCV) infection, continue to demonstrate high sustained viral response (SVR) rates against genotype 1 HCV, across patient types. Data show greater than 90 percent SVR were achieved in patients new to treatment and in patients who had previously failed treatment with pegylated interferon and ribavirin (null responders).
At least when it comes to an analysis of malpractice lawsuits, diagnostic errors - not surgical mistakes or medication overdoses - accounted for the largest fraction of claims, the most severe patient harm, and the highest total of penalty payouts. Diagnosis-related payments amounted to $38.8 billion between 1986 and 2010, they found.
The new analysis looked only at a subset of claims, those that rose to the level of a malpractice payout, but they estimate the number of patients suffering misdiagnosis-related, potentially preventable, significant permanent injury or death annually in the United States ranges from 80,000 to 160,000.
Suicide is the 10th leading cause of death in the United States. Statistics show that 38 percent of suicidal adults and 90 percent of youths had visited their primary care physicians in the 12 months prior to committing suicide.
An evidence review finds that while there are screening tools to help physicians identify adults at risk for suicide, there's no evidence that using these screening tools in primary care will actually prevent suicides. In adolescents, there are no proven primary care-relevant screening tools to identify suicide risk.
The U.S. Preventive Services Task Force reviewed evidence for upcoming recommendations on suicide screening and treatment for adults and adolescents and issued a paper.
Researchers have found a way to turn bone marrow stem cells directly into brain cells, bypassing current cumbersome techniques and bringing about the possibility of simpler and safer methods. Stem cell therapies derived from patients' own cells are widely hoped to one day treat spinal cord injuries, strokes and other conditions throughout the body, with no immune rejection.
"These results highlight the potential of antibodies as versatile manipulators of cellular functions," said Richard A. Lerner of The Scripps Research Institute (TSRI, principal investigator for the new study. "This is a far cry from the way antibodies used to be thought of—as molecules that were selected simply for binding and not function."
Blanket stereotypes are bad but they often come into existence for a reason; the problem becomes when everyone is labeled with the same brush. There is a common belief that some schools, high school and college, are giving athletes an easier time because they have physical skills but not academic ones, for example, and so all athletes become considered "dumb jocks".
Are college athletes victims of stereotype threat the way sociologists contend women and minorities in science classes are?
Thermoelectric power plants interact with climate, hydrology, and aquatic ecosystems while rivers serve as "horizontal cooling towers" — but at a cost to the environment, says a new analysis.
A coronal mass ejection (CME) is when our sun sends billions of tons of solar particles into space. A CME can affect electronic systems in satellites and NASA recently saw three.
