Scientists have reported that an experimental vaccine targeting one of the most common genetic drivers of pancreatic cancer, called mutant KRAS, is safe and generated a durable immune responses aimed at preventing the cancer.
In a new paper, researchers assess the complete landscape of a cancer's kinome expression and determine which kinases are acting up in a particular tumor. Since the proteins are relatively easy to target with drugs and plenty of kinase inhibitors already exist, the work shows that those particular kinases can be targeted with drugs and can even lead to potentially combining multiple drugs to target multiple kinases.
The researchers looked at RNA sequencing data from 482 samples of both cancerous and non-cancerous tissue and identified the most highly expressed kinases in individual breast cancer and pancreatic cancer samples. They found certain common themes.
Messier 106 looks like lots of other galaxies yet it hides a number of secrets. But now, it has slightly fewer than before, thanks to citizen science astronomers.
Scientists have created single layers of a naturally occurring rare mineral called tungstenite, or WS2, and the resulting sheet of stacked sulfur and tungsten atoms forms a honeycomb pattern of triangles that have been shown to have unusual light-emitting (photoluminescent) properties.
According to Mauricio Terrones, a professor of physics and of materials science and engineering at Penn State, the triangular structures have potential applications in optical technology; for example, for use in light detectors and lasers.
You don't see many really old, obese people whereas you see a lot of old thin people. It is reasonable to assume, exceptions aside, that obesity kills.
Unless you reach a certain age, it has been said. When it comes to seniors, research has reported an "obesity paradox" concluding that, at age 65 and older, having an elevated BMI won't shorten your lifespan, and may even extend it. A new study took another look at the numbers, finding the earlier research flawed. The paradox was a mirage: As obese Americans grow older, in fact, their risk of death climbs.
Most mammals, including humans, see in stereo and hear in stereo but the idea that mammals can also smell in stereo has been suspect.
A new study has found that the common mole (Scalopus aquaticus) relies on stereo sniffing to locate its prey. So there is at least one mammal that can, the researcher concludes.
How, when and where a pathogen is transmitted between two individuals in a population is crucial in understanding and predicting how a disease will spread and a new model seeks to lay the foundation for new zoonotic disease spread thinking
By outlining a predictive model of a spatial epidemic spread in a population of territorial animals and quantifying the instances of transmission events, the research team determined the propagation speed of a pathogen using parameters based on the knowledge of the demography of a species, the way animals wander and the degree of contagiousness of the disease.
People lose muscle mass, and find it harder to maintain, as they age, and so researchers have ben investigating ways to delay or counteract age-related muscle loss.
A study conducted by the Exercise Metabolism Research Group at McMaster University suggests that current guidelines for meat consumption are based on the protein needed to prevent deficiency without consideration for preservation of muscle mass, particularly for older individuals who are looking to maintain their muscle as they age.
President Obama has awarded 12 researchers the National Medal of Science. 11 inventors also received the National Medal of Technology and Innovation. Those are the highest government honors bestowed upon scientists, engineers and inventors.
This year's event marks the 50th presentation of the National Medals of Science, first awarded in 1963 by President John F. Kennedy. The recipients received their awards at a White House ceremony.
A new kind of pterosaur named Eurazhdarcho langendorfensis was a flying reptile from the time of the dinosaurs, according to scientists from the Transylvanian Museum Society in Romania, the University of Southampton in the UK and the Museau Nacional in Rio de Janiero, Brazil.
The fossilized bones come from the Late Cretaceous rocks of Sebeş-Glod in the Transylvanian Basin, Romania, which are approximately 68 million years old. The Transylvanian Basin is known for its many Late Cretaceous fossils, including dinosaurs of many kinds, as well as fossilized mammals, turtles, lizards and ancient relatives of crocodiles.
Sociologists have settled an important debate - namely, do women really want a man that does housework. The answer is 'no', according to an important new paper which found that married men and women who divide household chores in traditional ways report having more sex than couples who share the women's work.
figshare, a Digital Science portfolio company, has announced a new partnership with open access publisher Public Library of Science (PLoS) to host the supplemental data for all seven PLoS journals, as well as provide a widget that will enable PLoS users to view data in the articles in the browser alongside the content.
figshare provides a free way for researchers to publish, share and get credit for their research data, hosting videos, datasets, graphs, figures and images. By partnering with figshare, PLoS can host data accompanying their publications, making the data easier to access for future use. Through figshare's new widgets, users will also be able to visualize the research objects within the browser.
A new paper outlines the many pitfalls associated with simulation methods such as Monte Carlo algorithms and other commonly used molecular dynamics approaches.
