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Stem cells transplanted into the brains of mice generate more numerous and more mature nerve cells if the brain cells called astrocytes are not activated. This discovery at the Sahlgrenska Academy is an important step forward for stem cell research.
The study was performed by a research team at the Center for Brain Repair and Rehabilitation at the Sahlgrenska Academy.
The transplantation of stem cells and activation of the body's own stem cells could be a future treatment for several neurological disorders.

The discovery that eukaryotes, bacteria, and archaea coexisted 2.7 billion years ago came from chemical examination of shale samples, loaded with oily lipid remains of archaea found in a deep Canadian gold mine near Timmins, Ontario, about 400 miles north of Toronto. Previously it was thought that the three domains of life branched off around three billion years ago but being more specific was not possible.
Fabien Kenig, associate professor of earth and environmental sciences at the University of Illinois at Chicago, and his former doctoral student Gregory Ventura, spent nearly five years carefully analyzing the shale samples, originally to compare what they found with an earlier Australian study suggesting the presence of eukaryotes some 2.7 billion years ago.

Scientists know that information travels between brain cells along hairlike extensions called axons. For the first time, researchers have found that axons don’t just transmit information – they can turn the signal up or down with the right stimulation.
This finding may help scientists develop treatments for psychiatric disorders such as depression and schizophrenia in which it is thought that different parts of the brain do not communicate correctly with each other.

The Regea Institute for Regenerative Medicine, which operates under the University of Tampere in Finland, administered the first clinical stem cell therapy to two patients in cooperation with the Tampere University Hospital. The therapy was a success.
The patients suffered from severe, prolonged frontal sinusitis. An implant combining stem cells and biomaterial was inserted into the damaged bone. Since the therapy, the patients have been well and no longer suffer from frontal sinusitis.
Stem cell therapy was administered to patients with prolonged and severely symptomatic frontal sinusitis that destroyed bone tissue in the forehead. Other treatments such as traditional implants or fat tissue transplants failed to relieve infection.

The Internet is serving as a fertile medium for "HIV denialists" to spread false ideas about HIV/AIDS, which could have terrible public health consequences, say scientists in a policy paper in PLoS Medicine.
"It may seem remarkable that, 23 years after the identification of HIV, there is still denial that the virus is the cause of AIDS," say Tara Smith (University of Iowa College of Public Health) and Steven Novella (Yale University School of Medicine). But with the arrival of the Internet, HIV denialist organizations such as "Reappraising AIDS" have reignited their campaign to spread misinformation.

A team has examined over 300,000 genetic markers in thousands of asthmatic children and compared their data with those of healthy controls. The newly found gene, ORMDL3, is a promising object of research: it could help to improve the prevention and diagnosis of asthma, and possibly to develop a new therapy.
The scientists used the fact that the genetic material of different individuals shows differences. One type of DNA variants is called SNPs, short for “Single Nucleotide Polymorphisms”. They can be compared and statistically analysed.

By creating "Teflon" versions of natural antibiotics found in frog skin, a research team led by biological chemist E. Neil Marsh has made the potential drugs better at thwarting bacterial defenses, an improvement that could enhance their effectiveness.
Marsh and collaborators work with compounds called antimicrobial peptides (AMPs), which are produced by virtually all animals, from insects to frogs to humans. AMPs are the immune system's early line of defense, battling microbes at the first places they try to penetrate: skin, mucous membranes and other surfaces. They're copiously produced in injured or infected frog skin, for instance, and the linings of the human respiratory and gastrointestinal tracts also crank out the short proteins in response to invading pathogens.

Non-medicinal interventions are highly effective in preventing the behavioral and academic problems associated with Attention Deficit Hyperactivity Disorder (ADHD), according to a five-year study led by researchers at Lehigh University’s College of Education.
The study, titled “Project Achieve” and funded by the National Institute of Mental Health (NIMH), was the largest of its kind focusing on children aged 3 to 5 who have shown significant symptoms of ADHD. It also involved researchers from Lehigh Valley Hospital in Allentown, Pa.
The researchers, led by George DuPaul, professor of school psychology at Lehigh; Lee Kern, professor of special education at Lehigh; and Dr.

Researchers at Pacific Northwest National Laboratory are uniting theory, computation and experiment to discover exactly how heavy elements, such as uranium and technetium, interact in their environment.
As part of that effort, scientists have combined sensitive experimental measurements with fi rst principle electronic structure calculations to measure, and to really understand, the structural and bonding parameters of uranyl, the most common oxidation state of uranium in systems containing water.
The insights were achieved by PNNL scientist Bert de Jong and associates Gary Groenewold of Idaho National Laboratory and Michael Van Stipdonk of Wichita State University, employing the supercomputing resources of the William R.

Errors in the genetic code can give rise to cancer and a host of other diseases, but finding these errors can be more difficult than looking for the proverbial needle in the haystack. Now, scientists at Johns Hopkins have uncovered how the tiny protein-machines in cells tasked to search for such potentially life-threatening genetic damage actually recognize DNA errors.
Appearing online next week in Nature, the Hopkins team describes how the UDG enzyme (for uracil DNA glycosylase) scrutinizes the shape of DNA building blocks by holding onto them and testing their fit into a specially sized pocket. The UDG pocket holds onto mistakes only — the enzyme loses its grip on the right building blocks, which fall back in line with the rest of the DNA.

Do bats use their ultrasonic echolocation calls to recognize their own species?
A new study in the Journal of Biogeography by Danilo Russo and colleagues suggests that this is certainly the case for Rhinolophidae - horseshoe bats. These bats find their way in the dark and detect insect prey by emitting long ultrasound calls mainly made of a constant frequency. Different rhinolophid species show different frequency values. It has been proposed that such differences are large enough to allow recognition of conspecifics.
The study proved that in Sardinia, Mediterranean (Rhinolophus euryale) and lesser (R.. hipposideros) horseshoe bats show divergence in call frequency, spacing them out more than their conspecifics living in peninsular Italy (i.e. on the mainland).

Scientists at Pacific Northwest National Laboratory have discovered a way to increase the sensitivity of test strips that will enable creation of a portable biosensor that can address a major concern associated with incidents involving chemical or nerve agents - the need to quickly distinguish between individuals who have been exposed and the "worried well."
The sensor components resemble a pregnancy test strip and a small glucose testing meter. Its development will be discussed by principal investigator Yuehe Lin at the national meeting of the American Chemical Society.
Every disease has biomarkers, a change in the proteins that announces something is wrong.