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The molecular basis of obesity

The molecular basis of obesity

Researchers have discovered the molecule that links spontaneous physical activity and food intake in mice.
Scientists from the European Molecular Biology Laboratory (EMBL)say Bsx is the molecular link between spontaneous physical activity and food intake. Mice lacking the molecule show less spontaneous physical activity, perceive hunger signals differently and have a lower concentration of feeding hormones in their brain than normal mice. Being conserved across species Bsx might be a promising target for controlling diet-induced obesity in humans.

Aluminum foil that shines better than incandescent lights

Aluminum foil that shines better than incandescent lights

Researchers at the University of Illinois are developing panels of microcavity plasma lamps that may soon brighten people’s lives. The thin, lightweight panels could be used for residential and commercial lighting, and for certain types of biomedical applications.

Cross-sectional diagram of a flat lamp structure based on aluminum foil encapsulated in saphire and a thin glass coating. The lower right portion of the figure presents photographs at two magnifications of an electrode screen with diamond cross-sectional microcavities. The smallest graduation of the scale is 1 millimeter. Credit: University of Illinois

Even low doses of Ecstasy lead to memory loss

Even low doses of Ecstasy lead to memory loss

Ecstasy is an illicit recreational drug popular among young people, according to background information in the article. Research in both humans and animals suggests that the drug can harm the brain. Ecstasy may damage nerve cells that respond to the hormone serotonin, which is involved in mood, thinking, learning and memory.

Do financial incentives for physicians lead to better care?

Do financial incentives for physicians lead to better care?

By Chaim M. Bell and Wendy Levinson
Most doctors feel that they provide good to above-average patient care. However, Canadian physicians rarely receive feedback about their clinical performance or patient outcomes. Although both of us believe that we provide excellent patient care, we have never received any data on our clinical performance or patient outcomes compared with other physicians or benchmarks. How can we learn to improve our provision of care without objective measures of our performance?

Pay-for-performance incentive for physicians decreases smoking in patients, study says

Pay-for-performance incentive for physicians decreases smoking in patients, study says

By Christopher Millett, Jeremy Gray, Sonia Saxena, Gopalakrishnan Netuveli and Azeem Majeed
Many people with diabetes continue to smoke despite being at high risk of cardiovascular disease. We examined the impact of a pay-for-performance incentive in the United Kingdom introduced in 2004 as part of the new general practitioner contract to improve support for smoking cessation and to reduce the prevalence of smoking among people with chronic diseases such as diabetes.

How sneaky HIV escapes its cell

How sneaky HIV escapes its cell

Like hobos on a train, HIV, the virus that causes AIDS, uses a pre-existing transport system to leave one infected cell and infect new ones, Hopkins scientists have discovered. Their findings, published in the June issue of Plos Biology, counter the prevailing belief that HIV and other retroviruses can only leave and enter cells by virus-specific mechanisms.

Drug company funding of drug trials greatly influences outcome

Drug company funding of drug trials greatly influences outcome

In head-to-head trials of two drugs, the one deemed better appears to depend largely on who is funding the study, according to an analysis of nearly 200 statin-drug comparisons carried out between 1999 and 2005.
UCSF researchers examined 192 published results of trials comparing one cholesterol-lowering statin drug to another, or to a non-statin drug.

Geoengineering -- A quick fix with big risks

Geoengineering -- A quick fix with big risks

Radical steps to engineer Earth’s climate by blocking sunlight could drastically cool the planet, but could just as easily worsen the situation if these projects fail or are suddenly halted, according to a new computer modeling study.
The experiments, described in the June 4 early online edition of The Proceedings of the National Academy of Sciences, look at what might happen if we attempt to slow climate change by “geoengineering” a solar filter instead of reducing carbon dioxide emissions. The researchers used a computer model to simulate a decrease in solar radiation across the entire planet, but assumed that that the current trend of increasing global carbon dioxide emissions would continue for the rest of this century.

The link between Khat and mental illness

The link between Khat and mental illness

Commonly used by around 10 million people in east Africa and countries in the Arabian peninsula, chewing khat for its stimulant properties has also become popular in the UK among immigrants of the Somali, Yemeni and Ethiopian communities. Whilst it is reported to have cultural functions, it is also increasingly reported to be associated with social and medical problems including anti-social behaviour, unemployment, psychoses, depression, and self-neglect.

Go to 3DChem to interact with a 3D model of the Khat structure

Mysterious radio waves on Titan

Mysterious radio waves on Titan

The Huygens Atmosphere Structure Instrument (HASI) scored a first in 2005 by measuring the electrical conductivity of Titan’s atmosphere. The results hint at a new way to investigate the subsurface layers of Titan and could provide insight into whether or not Titan has a subsurface ocean.
The Permittivity, Waves and Altimetry (PWA) sensor on Huygens detected an extremely low frequency (ELF) radio wave during the descent. It was oscillating very slowly for a radio wave, just 36 times a second, and increased slightly in frequency as the probe reached lower altitudes.

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Fuel cells from lobster shells

Fuel cells from lobster shells

Discarded crab and lobster shells may be the key to prolonging the life of microbial fuel cells that power sensors beneath the sea, according to a team of Penn State researchers.
To produce energy, microbial fuel cells need organic material for the microbes to consume. However, deep sea sediments can be surprisingly devoid of organic material because living things in the photic zone – the area where light penetrates the water – are continuously recycled and little falls to the ocean floor. An absence of organics limits the lifetime of marine microbial fuel cells.

Cognitive lock-in: teaching an old dog new tricks

Cognitive lock-in: teaching an old dog new tricks

The ability to learn from experience is of central importance to human existence. It allows us to acquire many of the skills we need to complete a wide variety of complicated, multi-step tasks in an efficient manner. It also creates habit – a critical, if often overlooked factor in the product and service choices consumers make. An important new study from the Journal of Consumer Research demonstrates how this “cognitive lock-in” can cause us to remain loyal to a product, even if objectively better alternatives exist.
“We find that consumers typically are not aware that this mechanism is a powerful determinant of the choices they make,” write Kyle B.