Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Malignant melanoma is one of the deadliest forms of skin cancer. Nearly 60,000 new cases of melanoma are expected in 2007, and 8,100 deaths are expected to occur.
Higher levels of a protein called S-100 in patients with melanoma may correlate with a higher risk of having the disease return, say researchers at the University of Pittsburgh Cancer Institute.
A drug described by some people as a “genius pill” for enhancing cognitive function provided relief to a small group of Rochester breast cancer survivors who were coping with a side effect known as “chemo-brain,” according to a University of Rochester Medical Center study.
Sixty-eight women, who had completed treatment for breast cancer, participated in an eight-week clinical trial testing the effects of modafinil (Provigil). All women took the drug for the first four weeks. During the next month half of the women continued to receive the drug while the other half took an identical looking placebo pill.
Researchers have identified novel genetic mutations that are linked to hereditary diffuse gastric cancer, with these mutations being due to both independent mutational events and common ancestry, according to a study in the June 6 issue of JAMA.
What did dinosaurs hear? Probably a lot of low frequency sounds, like the heavy footsteps of another dinosaur, if University of Maryland professor Robert Dooling and his colleagues are right. What they likely couldn't hear were the high pitched sounds that birds make.
This diagram illustrates the relationship among archosaurs, which includes dinosaurs, crocodiles and birds. The drawings are of the inner ear structure of the different species. The numbers to the left are the time scale in million years. Today's birds are the closest living relatives of the extinct dinosaurs. Credit: University of Maryland
An architect pursuing a Ph.D. at the Technion-Israel Institute of Technology and his colleague have devised a low-tech way to collect dew from the air and turn it into fresh water. Their invention recently won an international competition seeking to make clean, safe water available to millions around the world.
WatAir, shown here in an artistic rendering, could produce an unlimited supply of fresh water even in remote and polluted places.
Last year, a groundbreaking international project found that a group of Japanese patients with advanced non-small cell lung cancer survived longer —and had a higher rate of side effects — than U.S. patients with the same diagnosis,.when both groups were given two well-known drugs for the disease.
Flaxseed, an edible seed that is rich in omega 3-fatty acids and fiber-related compounds known as lignans, is effective in halting prostate tumor growth, according to a study led by Duke University Medical Center researchers. The seed, which is similar to a sesame seed, may be able to interrupt the chain of events that leads cells to divide irregularly and become cancerous.
"Our previous studies in animals and in humans had shown a correlation between flaxseed supplementation and slowed tumor growth, but the participants in those studies had taken flaxseed in conjunction with a low-fat diet," said Wendy Demark-Wahnefried, Ph.D., a researcher in Duke's School of Nursing and lead investigator on the study.
Any number of things can go wrong in the cells of the body to cause cancer -- and clinicians can't tell by just looking at a tumor what exactly triggered the once normal cells to turn cancerous.
New tests developed by researchers at Duke University can determine the precise patterns among thousands of genes to identify the cascade of events, or pathways, that led to the cancer.
Colgate anthropology professor Allan Maca and a team of researchers have found a previously unknown tomb in Copán, Honduras, dating back to the 7th century A.D. that contained the skeleton of an elite member of ancient Maya society in the city.
The unusual characteristics of the tomb’s construction, the human remains, and the artifacts found near the body, according to Maca, paint a picture of an urban state that was more politically complex and culturally diverse than was previously thought.
A team of biomedical engineers has developed a computer model that makes use of more or less predictable “guesstimates” of human muscle movements to explain how the brain draws on both what it recently learned and what it’s known for some time to anticipate what it needs to develop new motor skills.
The engineers exploited the fact that all people show similar “probable” learning patterns and use them to develop and fine tune new movements, whether babies trying to walk or stroke patients re-connecting brain-body muscle links.
Researchers at the University of California, Santa Cruz, have performed atomic spectroscopy with integrated optics on a chip for the first time, guiding a beam of light through a rubidium vapor cell integrated into a semiconductor chip.
Based on the interactions of light and matter, spectroscopy is often used to identify substances by the wavelengths of light they absorb or emit. Conventional systems have many large components, whereas the compact, fully planar device developed at UCSC enables the study of atoms and molecules on a chip-based platform with integrated optics, said Holger Schmidt, associate professor of electrical engineering.
New charcoal and plant microfossil evidence from Mexico’s Central Balsas valley links a pivotal cultural shift, crop domestication in the New World, to local and regional environmental history. Agriculture in the Balsas valley originated and diversified during the warm, wet, postglacial period following the much cooler and drier climate in the final phases of the last ice age.
A significant dry period appears to have occurred at the same time as the major dry episode associated with the collapse of Mayan civilization, Smithsonian researchers and colleagues report.