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A team led by Dana-Farber Cancer Institute scientists has developed a more human-like mouse model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.
Ronald A. DePinho, MD, of Dana-Farber has created mice that form tumors that are more genetically complex and unstable -- and therefore a better stand-in for human cancers -- than those of conventional genetically engineered mouse models of cancer. To characterize these mouse tumors, DePinho collaborated with Lynda Chin, MD, also at Dana-Farber, to perform high-resolution array-CGH profiling, a genome-scanning technology that can define regions of DNA abnormalities.

Coffee is a habit for more than 50 percent of Americans, who drink, on average, 2 cups per day. This widely consumed beverage is regularly investigated and debated for its impact on health conditions from breast cancer to heart disease. Among its complex effects on the body, coffee or its components have been linked to lower insulin and uric acid levels on a short-term basis or cross-sectionally. These and other mechanisms suggest that coffee consumption may affect the risk of gout, the most prevalent inflammatory arthritis in adult males.

MIT researchers have undertaken a first-of-its-kind analysis of bone's mechanical properties and discovered new things about how a bone absorbs energy. The insights gained from this work could lead to the creation of new, tougher materials.

MIT researchers created this nanoscale map of the stiffness of bone. Image courtesy / Ortiz Lab, MIT
The researchers' up-close-and-personal look at bone probes its fundamental building block—a corkscrew-shaped protein called collagen embedded with tiny nanoparticles of mineral—at the level of tens of nanometers, or billionths of a meter. A human hair, by comparison, is 80,000 nanometers in diameter.

Compared to math teachers in the high-achieving nations of Hong Kong and Japan, teachers in the United States offer less of certain supports that could help students learn more. This could contribute to the lower performance among U.S. students on international math tests, a UCI researcher discovered.

At four months, babies can tell whether a speaker has switched to a different language from visual cues alone, according to a University of British Columbia study.
Researcher Whitney Weikum found that infants are able to discern when a different language is spoken by watching the shapes and rhythm of the speaker's mouth and face movements.

If you do something positive for your mate, does it matter why? The answer is yes, according to new research from University of Rochester research assistant professor Heather Patrick. She will unveil a study at a Toronto conference later this month that shows both small sacrifices, like doing the dishes for your partner, and big ones, like moving across the country for a new job he or she really wants, mean more if you do them because you genuinely want to.

Or get the kids to do them and make the wife a nice bath

An extraordinary underwater trackway with 12 consecutive prints provides the most compelling evidence to-date that some dinosaurs were swimmers. The 15-meter-long trackway, located in La Virgen del Campo track site in Spain's Cameros Basin, contains the first long and continuous record of swimming by a non-avian therapod dinosaur.
 

When Dutch astronomer Willem de Sitter proposed a static model of the universe in the early 1900s, he was some 3 trillion years ahead of his time.
Now, physicists Lawrence Krauss from Case Western Reserve University and Robert J. Scherrer from Vanderbilt University predict that trillions of years into the future, the information that currently allows us to understand how the universe expands will have disappeared over the visible horizon. What remains will be "an island universe" made from the Milky Way and its nearby galactic Local Group neighbors in an overwhelmingly dark void.

Lawrence Krauss

Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania and the Dana-Farber Cancer Institute describe in this week’s issue of Science a new candidate breast-cancer susceptibility gene. The Rap80 gene is required for the normal DNA-repair function of the well-known breast cancer gene BRCA1.

Upper panels: BRCA1 and Rap80 are recruited to the same structures at DNA damage sites in human cells treated with ionizing radiation. The merge panel is a digital overlay of the BRCA1 and Rap80 panels. Each circle represents a nucleus within one cell. Lower panels: Rap80 targets BRCA1 to DNA damage sites.

The discovery of a flexible genetic coding in leaf-cutting ants sheds new light on how one of nature's ultimate self-organising species breeds optimum numbers of each worker type to ensure the smooth running of the colony.
Research at the University of Leeds shows that despite an inherited genetic pre-disposition to grow into a particular worker caste, ant larvae can be triggered by environmental stimuli to switch development depending on colony's workforce needs.

Cells have the remarkable ability to keep track of their genetic contents and -- when things go wrong – to step in and repair the damage before cancer or another life-threatening condition develops.
But precisely how cells monitor the integrity of their genomes, identify problems, and intervene to repair broken or miscoded DNA has been one of nature's closely held secrets. Now, however, a report in the journal Science describes a new database developed by a team of researchers from the Howard Hughes Medical Institute at Harvard Medical School that is providing the first detailed portrait of the army of more than 700 proteins that helps maintain DNA’s integrity.

High uric acid levels in the blood are a precursor of gout, the most common inflammatory arthritis in adult men. It is believed that coffee and tea consumption may affect uric acid levels but only one study has been conducted to date. A new large-scale study published in the June 2007 issue of Arthritis Care & Research (http://www.interscience.wiley.com/journal/arthritiscare) examined the relationship between coffee, tea, caffeine intake, and uric acid levels and found that coffee consumption is associated with lower uric acid levels but that this appears to be due to components other than caffeine.