News Articles

New research from Columbia's Primate Cognition Laboratory has demonstrated for the first time that monkeys could acquire meta-cognitive skills: the ability to reflect about their thoughts and to assess their performance.
The study was a collaborative effort between Herbert Terrace, Columbia professor of psychology & psychiatry, and director of its Primate Cognition Laboratory, and two graduate students, Lisa Son — now professor of psychology at Barnard College — and UCLA postdoctoral researcher Nate Kornell.

The test used touch-screen technology and a multiple-choice format. Six novel photographs were presented at the beginning of each trial, one at a time.

Cilia, tiny hair-like structures that propel mucus out of airways, have to agree on the direction of the fluid flow to get things moving. Researchers at the Salk Institute for Biological Studies discovered a novel two-step mechanism that ensures that all cilia beat in unison.
Their study, published in Nature, reveals that during early embryonic development, cilia point more or less in the general direction of the body's back end and start creating a weak flow. During the following refinement phase, all cilia get in line and trim their sails to the prevailing winds.

Two ciliated cells showing cilia (green) and basal bodies (red).

Huntington’s disease, an inherited neurodegenerative disorder that affects roughly 30,000 Americans, is incurable and fatal. But a new discovery about how cells repair their DNA points to a possible way to stop or slow the onset of the disease. The research was funded by the National Institutes of Health (NIH).
"As so often happens, basic research on a fundamental biological process—in this case, enzymes involved in DNA repair—leads to new insights about how diseases arise and new approaches for treating or preventing them," said NIH Director Elias A. Zerhouni, M.D.

Artistic rendering of a broken DNA helix emanating from a mouse nerve cell.

Ultra-hard materials are used for everything from drills that bore for oil and build new roads to scratch-resistant coatings for precision instruments and the face of your watch.
UCLA scientists are now reporting a promising new approach to designing super-hard materials, which are very difficult to scratch or crack.

UCLA scientists have made rhenium diboride, an “ultra-hard material.” Rhenium diboride is seen here in powder form (left), made from heating the elements in a furnace, and as a pellet made by a procedure called arc melting. Credit: UCLA

An effective way to fight leukemia might be to knock out a specific protein that protects cancer cells from dying, a new study shows.
The findings suggest that a drug that can block this "survival protein" might on its own be an effective therapy.

Using a new type of drug that targets a specific genetic defect, researchers at the University of Pennsylvania School of Medicine, along with colleagues at PTC Therapeutics Inc. and the University of Massachusetts Medical School, have for the first time demonstrated restoration of muscle function in a mouse model of Duchenne's muscular dystrophy (DMD).

Crohn’s disease is a chronic relapsing inflammatory disorder of the intestinal tract that affects an estimated 0.15% of people in the developed world. Common symptoms include abdominal pain and diarrhea, but the disorder is often associated with debilitating clinical complications. Researchers from the University of Liège, Belgium, have now uncovered an important clue to the susceptibility of individuals to this disease.

Scientists have discovered one of the reasons why bladder cancer is so much more prevalent in men than women: A molecular receptor or protein that is much more active in men than women plays a role in the development of the disease. The finding could open the door to new types of treatment with the disease.
In an article in the April 4 issue of the Journal of the National Cancer Institute, Chawnshang Chang, Ph.D., of the University of Rochester Medical Center and colleagues show that the androgen receptor, which is central to the action of testosterone and other hormones that are much more plentiful in men than women, appears to play a key role in the disease.

Serotonin is a major signaling chemical in the brain, and it has long been thought to be involved in aggressive behavior in a wide variety of animals as well as in humans. Another brain chemical signal, neuropeptide Y (known as neuropeptide F in invertebrates), is also known to affect an array of behaviors in many species, including territoriality in mice. A new study by Drs. Herman Dierick and Ralph Greenspan of The Neurosciences Institute in San Diego shows that these two chemicals also regulate aggression in the fruit fly, Drosophila melanogaster.

A new study says targeting smaller (¡Ü5 mm) lesions does little to significantly reduce the incidence of colorectal cancer (CRC) and, in fact, results in extremely high financial costs and a large proportion of adverse events. Published in the June 1, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer Society, a cost-benefit analysis study says the low malignancy rate among so-called diminutive polyps gives virtual colonoscopy with removal of lesions 6 mm or greater the best estimated value per life year gained and with fewer complications.

Mayo Clinic researchers, along with collaborators from the National Institutes of Health (NIH) and University of Oslo, Norway, have discovered that a miscue of the body’s genetic repair system may cause Huntington’s disease, a fatal condition that affects 30,000 Americans annually by destroying their nervous system. Until now, no one knew how Huntington’s begins, only that it is incurable. The findings appear in the online issue of the journal Nature.

The most recent census of mountain gorillas in Uganda’s Bwindi Impenetrable National Park—one of only two places in the world where the rare gorillas exist—has found that the population has increased by 6 percent since the last census in 2002, according to the Uganda Wildlife Authority, the Wildlife Conservation Society, the Max Planck Institute of Anthropology and other groups that participated in the effort.