Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Craftsmen tile walls or floors by hand; but how can you get an ordered monolayer onto a substrate when the "tiles" are microscopically small instead of big and easy to handle? Previously, self-assembly processes have been the method of choice for this scale. Korean researchers have now come to the realization that even such tiny components can be arranged in a "do-it-yourself" method. As they describe in the journal Angewandte Chemie, their manually produced monolayers of microcrystals are qualitatively superior to the self-assembled variety.
University of Chicago scientists will demonstrate how to incinerate a white dwarf star in unprecedented detail at the “Paths to Exploding Stars” conference on Thursday, March 22, in Santa Barbara, Calif.
White dwarf stars pack one and a half times the mass of the sun into an object the size of Earth. When they burn out, the ensuing explosion produces a type of supernova that astrophysicists believe manufactures most of the iron in the universe.
The theory that Earth once underwent a prolonged time of extreme global freezing has been dealt a blow by new evidence that periods of warmth occurred during this so-called 'Snowball Earth' era.
Analyses of glacial sedimentary rocks in Oman, published online today in Geology, have produced clear evidence of hot-cold cycles in the Cryogenian period, roughly 850-544 million years ago. The UK-Swiss team claims that this evidence undermines hypotheses of an ice age so severe that Earth's oceans completely froze over.
Scientists from the NIOZ Royal Netherlands Institute for Sea Research obtained for the first time a detailed temperature record for tropical central Africa over the past 25,000 years. They did this in cooperation with a German colleague from the University of Bremen, The scientists developed an entirely new method to reconstruct the history of land temperatures based on the molecular fossils of soil bacteria. They applied the method to a marine sediment core taken in the outflow of the Congo River. This core contained eroded land material and microfossils from marine algae. The results show that the land environment of tropical Africa was cooled more than the adjacent Atlantic Ocean during the last ice-age.
Fresh evidence that suggests monkeys can learn skills from each other, in the same manner as humans, has been uncovered by a University of Cambridge researcher.
Dr Antonio Moura, a Brazilian researcher from the Department of Biological Anthropology, has discovered signs that Capuchin monkeys in Brazil bang stones as a signalling device to ward off potential predators.
Tissue engineering is a relatively new field of basic and clinical science that is concerned, in part, with creating tissues that can augment or replace injured, defective, or diseased body parts. The approach to fabricating the tissues involves adding specific cell types to grow on a polymer scaffold having the shape of the tissue to be restored. The scaffold gradually disappears, while the cells continue developing in the scaffold shape. With the use of non-human animal cells, there has been considerable recent progress made in the engineering of skin, bladder, cartilage, and several other tissues.
The ribosome is the protein-producing nanomachine in cells that keeps the human body cranking along.
Researchers at Purdue University and The Catholic University of America have discovered the structure of an enzyme essential for the operation of "molecular motors" that package DNA into the head segment of some viruses during their assembly.
The enzyme, called an ATPase, provides energy to run the motor needed to insert DNA into the capsid, or head, of the T4 virus, which is called a bacteriophage because it infects bacteria. The same kind of motor, however, also is likely present in other viruses, including the human herpes virus.
This image depicts the structure of the T4 virus, called a bacteriophage because it infects bacteria.
Today, during the 85th General Session of the International Association for Dental Research, scientists are reporting that the use of saliva for clinical detection of major human diseases is only a few years away. Intense research is ongoing to discover diagnostic saliva biomarkers. A necessary prerequisite is to know, in a comprehensive manner, the informative biomarkers in saliva: the diagnostic alphabets. Like languages, which are synthesized from a foundation of alphabets, there are multiple diagnostic languages and thus diagnostic alphabets in saliva. The salivary proteome and the salivary transcriptome are two diagnostic alphabets that are ready for translational and clinical applications.
UCF's Conservatory Theatre and its partners are pushing the envelope of traditional theater by not only bringing it into the 21st Century, but launching it into the 22nd.
Using new techniques that merge the Internet 2 with traditional stage theatre, the University of Central Florida, Bradley University in Illinois and the University of Waterloo in Canada performed a play that put actors from Florida and Canada on the stage in Illinois without them ever leaving their respective campuses.
Geneticists have discovered a new gene that may put individuals at higher risk of developing cardiovascular disease.
The identification of the gene, called kalirin, implicates a biological mechanism never before linked to cardiovascular disease, according to the Duke researchers who led the study. Further study of this new clue could lead to novel ways to treat or even prevent the disease, the researchers said.
"The ultimate goal is to determine who will develop cardiovascular disease," said lead study investigator Liyong Wang, Ph.D., a research associate at the Duke Center for Human Genetics. "Our discovery could lead to a clinical tool for assessing a person's risk of coronary artery disease, so that physicians can try to prevent the disease from progressing."
Using ESO's Very Large Telescope, an international team of astronomers has shown how to use the chemical composition of stars in clusters to shed light on the formation of our Milky Way. This discovery is a fundamental test for the development of a new chemical tagging technique uncovering the birth and growth of our Galactic cradle.
The formation and evolution of galaxies, and in particular of the Milky Way - the 'island universe' in which we live, is one of the major puzzles of astrophysics: indeed, a detailed physical scenario is still missing and its understanding requires the joint effort of observations, theories and complex numerical simulations.