Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
When man made his way out of Africa some 60,000 years ago to populate the world, he was not alone: He was accompanied by the bacterium Helicobacter pylori, which causes gastritis in many people today. Together, man and the bacterium spread throughout the entire world. This is the conclusion reached by an international team of scientists led by Mark Achtman from the Max Planck Institute for Infection Biology in Berlin, Germany. The researchers also discovered that differences developed in the genetic makeup of the bacteria populations, just as it did in that of the various peoples of the world.
What caused the extinction of the woolly rhinoceros ten thousand years ago from an area in Europe covering the coasts of the Arctic Ocean in the north to the coasts of the Mediterranean in the south? What caused the extinction of the mammoth while other ice age mammals like the musk ox just barely survived to present day? A new scientific methodological approach to detect genetic material will help researchers to solve the many mysteries of the past.
"I'm confident that the new methodological approach, will be of great importance to molecular biology", says Professor Eske Willerslev at the Centre for Ancient Genetics, University of Copenhagen, Denmark. One of his PhD students recently came up with a brilliant idea.
The rise of multicellular animals about 540 million years ago was a turning point in the history of life. A group of Finnish scientists suggests a new climate-biosphere interaction mechanism for the underlying processes in a new study, which will be published on February 14, 2007 in PLoS ONE, the international, peer-reviewed, open-access, online publication from the Public Library of Science (PLoS).
The theory invokes cold, ice-containing climates as a key precursor for multicellular life. If the model turns out to be correct, one can assume that complex life might exist also around stars which are more massive and short-lived than the Sun.
While previous biomedical research studies have found that genetics and race increase risk for some diseases, a new look into how researchers study genetic triggers of type 2 diabetes suggests that defining race remains an inexact science, with social and historic facts mixing with biology throughout the research process.
The new study by a UC Irvine anthropologist calls into question not only how race-specific information is being gathered and interpreted by the medical community, but how it is presented to the public through media and pharmaceutical marketing.
Anthropologist Michael Montoya followed the trail of DNA samples from the moment they were donated by people living along the U.S.-Mexican border, to the eventual publication of findings in scientific journals.
Imagine a car that accelerates from zero to 60 in 250 feet, and then rockets to 120 miles per hour in just one more inch.
That's essentially what a collaboration of more than a dozen accelerator physicists has accomplished, using electrons for their racecars and plasma for the afterburners. Because electrons already travel at near light's speed in an accelerator, the physicists actually doubled the energy of the electrons, not their speed.
The blue streak in this photograph shows the dramatic gain in energy made by some of the electrons in a bunch after passing through plasma (ionized gas).
When the next big earthquake hits a region like San Francisco, Natural Sciences and Engineering Research Council (NSERC) grantee Kristy Tiampo wants to ensure that communities will not only be able to evacuate, but also rebuild.
This is why Tiampo, the NSERC and Benfield/ICLR Industrial Research Chair in Earthquake Hazard Assessment, is involved in an international effort to improve earthquake forecasting. She studied earthquake engineering in California as an undergraduate, and is now using her research to build better forecasting maps in Canada and other countries.
New research published in the March issue of Psychological Science suggests that efforts to advocate improved statistical practices in psychological research may be paying off.
Geoff Cumming, Fiona Fidler and colleagues at La Trobe University in Melbourne, Australia sought to examine whether guidelines set forth in 1999 by the American Psychological Association’s Task Force on Statistical Inference (TSFI) had been implemented in psychological research.
The authors analyzed articles from 10 leading international psychology journals from 1998 to 2006, focusing on three practices central to the statistical reform debate: Null hypothesis significance testing, confidence intervals and figures with error bars.
Ghostly galaxies composed almost entirely of dark matter speckle the universe. Unlike normal galaxies, these extreme systems contain very few stars and are almost devoid of gas. Most of the luminous matter, so common in most galaxies, has been stripped away, leaving behind a dark matter shadow. These intriguing galaxies-known as dwarf spheroidals-are so faint that, although researchers believe they exist throughout the universe, only those relatively close to Earth have ever been observed.
While scholars have put forth various assessments for the location of the Second Temple in Jerusalem, a Hebrew University of Jerusalem professor says that archaeological remains that have so far been ignored by scholars point to the exact location, which is in a spot that differs from prevailing opinion.
The location identified by Prof. Joseph Patrich of the Hebrew University Institute of Archaeology places the Temple and its corresponding courtyards, chambers and gates in a more southeasterly and diagonal frame of reference than have earlier scholars.
Drawing (Temple1) shows Prof. Patrich’s description of the location of the Temple compound (the rectangle defined by a solid line in the center of the drawing).
A robotic therapy device may help people regain strength and normal use of affected hands long after a stroke, according to a University of California, Irvine study.
Stroke patients with impaired hand use reported improved ability to grasp and release objects after therapy sessions using the Hand-Wrist Assisting Robotic Device (HOWARD). Each patient had at least moderate residual weakness and reduced function of the right hand, although the affected hands were neither totally paralyzed nor unable to feel.
This NASA Hubble Space Telescope image shows the colorful "last hurrah" of a star like our Sun. The star is ending its life by casting off its outer layers of gas, which formed a cocoon around the star's remaining core. Ultraviolet light from the dying star then makes the material glow. The burned-out star, called a white dwarf, appears as a white dot in the center. Our Milky Way Galaxy is littered with these stellar relics, called planetary nebulae. Hubble's Wide Field Planetary Camera 2 captured this image of planetary nebula NGC 2440 on Feb. 6, 2007.
A University of Calgary archaeologist has found the first prehistoric evidence of chimpanzee technology, adding credence to the theory that some of humanity's behavioral hallmarks were actually inherited by both humans and great apes from a common ancestor.
Dr. Julio Mercader, one of the few archaeologists in the world who studies the material culture of great apes, especially chimpanzees, uncovered stone 'hammers' last year in the Taï rainforest of Africa's Côte D'Ivoire (Ivory Coast) that date back 4,300 years.
Examples of some of the stones that were excavated. Analysis shows they were used by chimpanzees some 4,300 years ago to crack nuts.