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Nine New X Chromosome Genes Associated With Learning Disabilities

Nine New X Chromosome Genes Associated With Learning Disabilities

A collaboration between more than 70 researchers across the globe has uncovered nine new genes on the X chromosome that, when knocked-out, lead to learning disabilities. The international team studied almost all X chromosome genes in 208 families with learning disabilities - the largest screen of this type ever reported. 

Genome-Wide Association Study Finds Four Possible Risk Factors For Ovarian Cancer

Genome-Wide Association Study Finds Four Possible Risk Factors For Ovarian Cancer

Cancer researchers say a large genome-wide association study (GWAS) that spanned three continents has identified four chromosome locations with genetic changes that are likely to alter a woman's risk of developing ovarian cancer. Researchers say that while more needs to be learned about the function of the specific chromosomal regions involved in susceptibility, the discoveries move them a major step closer to individualized risk assessments for ovarian cancer. In the future, women at greatest risk due to these and other inherited changes may be offered increased surveillance or preventive measures.

A Key Step Toward A Safer Strep Vaccine

A Key Step Toward A Safer Strep Vaccine

An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have identified the genes encoding a molecule that famously defines Group A Streptococcus (strep), a pathogenic bacterial species responsible for more than 700 million infections worldwide each year.
The findings, published online in the June 11 issue of Cell Host&Microbe, shed new light on how strep bacteria resists the human immune system and provides a new strategy for developing a safe and broadly effective vaccine against strep throat, necrotizing fasciitis (flesh-eating disease) and rheumatic heart disease.

Aboriginal Women And High Rates Of Fetal Alcohol Syndrome

Aboriginal Women And High Rates Of Fetal Alcohol Syndrome

 Fetal Alcohol Syndrome is one of a group of preventable, lifelong conditions (the Fetal Alcohol Spectrum Disorders) that may result from high alcohol use in pregnancy. It can cause low IQ, delays in development and problems with learning, academic achievement, behavior, motor function, speech and language and memory.
It is also characterized by abnormal facial features and poor growth, before or after birth. 
One in eight children born in 2002 or 2003 and living in remote Fitzroy Valley communities in Western Australia have Fetal Alcohol Syndrome, finds the The Lililwan study published today in the Journal of Paediatrics and Child Health.

'Healthy' Fat Tissue Could Be Key To Reversing Type 2 Diabetes

'Healthy' Fat Tissue Could Be Key To Reversing Type 2 Diabetes

Preventing inflammation in obese fat tissue may hold the key to preventing or even reversing type 2 diabetes, new research has found.
Researchers from Melbourne's Walter and Eliza Hall Institute and the RIKEN Institute, Japan found they could 'reverse' type 2 diabetes in laboratory models by dampening the inflammatory response in fat tissue.
Dr Ajith Vasanthakumar, Dr Axel Kallies and colleagues from the institute discovered that specialised immune cells, called regulatory T cells (Tregs), played a key role in controlling inflammation in fat tissue and maintaining insulin sensitivity.

Blocking CaMKK2 Enzyme Promotes Weight Loss

Blocking CaMKK2 Enzyme Promotes Weight Loss

Imagine being able to tone down appetite and promote weight loss, while improving the body’s ability to handle blood sugar levels.
That’s just what Tony Means, PhD, and his team at the Duke University Medical Center were able to do when they blocked a brain enzyme, CaMKK2, in mice.
“We believe we have identified an important drug development target that could potentially turn into a metabolic triple play: appetite control, weight loss and blood sugar management,“ said Means, who is the Nanaline H. Duke Professor and Chairman of Pharmacology and Cancer Biology.

The Key To Maintaining Muscle Strength While We Age

The Key To Maintaining Muscle Strength While We Age

What causes us to lose muscle strength as we age and how exercise can prevent it from happening has never been thoroughly understood, but McMaster University researchers have discovered a key protein required to maintain muscle mass and muscle strength during aging.
This important finding means new and existing drugs targeting the protein may potentially be used to preserve muscle function during aging.
"We found that the body's fuel gauge, AMP-activated protein kinase (AMPK), is vital to slow muscle wasting with aging," said Gregory Steinberg, the study's senior author and professor of medicine at the Michael G. DeGroote School of Medicine. He is also co-director of MAC-Obesity, the Metabolism and Childhood Obesity Research Program at McMaster.

Enjoy Sugar Again: High Carb Diet On Par With Caloric Restriction In Boosting Health

Enjoy Sugar Again: High Carb Diet On Par With Caloric Restriction In Boosting Health

Caloric restriction in mice has been touted for accomplishing everything from increasing longevity to lowering cholesterol, but those animals are weaned on that from birth, and humans will go to jail trying it with their children.It may be unnecessary - and the diet advice we have gotten for the last 30 years may be also. A new study found that a diet of high carbohydrates and low protein - the opposite of what has been recommended - improves insulin sensitivity and can provide benefits similar to those obtained with calorie restriction.

Misunderstood Or Fraud? Why Doctors Should Never Recommend Homeopathy

Misunderstood Or Fraud? Why Doctors Should Never Recommend Homeopathy

Should doctors recommend homeopathy? Sometimes placebos work, that is why placebo has an Effect named after it and, because they are inert, they can't do any harm. But when patients or taxpayers are coughing up money for it, the issue is more murky.
Peter Fisher, Director of Research at the Royal London Hospital for Integrated Medicine, says that of all the major forms of complementary medicine, homeopathy is the most misunderstood. He says how regular medicine reviews homeopathy is. For example, in a recent report by the Australian National Health and Medical Research Council which stated that "there are no health conditions for which there is reliable evidence that homeopathy is effective." 

Researchers Discover Key Mechanism To Emergence Of Deadly Strep Bacteria

Researchers Discover Key Mechanism To Emergence Of Deadly Strep Bacteria

The incidence of serious strep infections has risen dramatically in the last three decades, and this increase is largely attributed to the spread around the globe of a single strain of strep known as the invasive M1T1 clone.
Researchers at the University of California, San Diego (UCSD) School of Medicine and the University of Wollongong in Australia have discovered that, 30 years ago, a virus infected the strep bacteria – creating a deadly strain of “flesh-eating” bacteria that has evolved to produce serious human infections worldwide.