In the 1980s, scientists captured the precise mechanics of a protein machine. It looked strange, to researchers its tall thin structure with stubby legs invoked the enchanted broomstick that stole the show in "The Sorcerer's Apprentice" segment of Disney's 1940 Fantasia film.
(Vienna, October 17, 2014) Two new pill-only regimens that rapidly cure most patients with genotype 1 hepatitis C (HCV) infection could soon be widely prescribed across Europe. Two recently-published studies1,2 confirmed the efficacy and safety of combination therapy with two oral direct-acting antiviral agents (DAAs), with around 90% of patients cured after just 12-weeks of treatment.
Computer simulations show how bacteria are able to destroy antibiotics, focusing on the role of enzymes in the bacteria which split the structure of the antibiotic and stop it working, making the bacteria resistant.
The new findings show that it's possible to test how enzymes react to certain antibiotics and thus design new antibiotics with a much lower risk of resistance, and even to choose the best medicines for specific outbreaks.
Using QM/MM - quantum mechanics/molecular mechanics simulations – the research team were able to gain a molecular-level insight into how enzymes called 'beta-lactamases' react to antibiotics.
A region of human chromosome 16, known as 16p11.2, is prone to genetic changes in which segments of DNA are deleted or duplicated and is considered to be one of the leading candidates for genetic causes of autism, schizophrenia, and other conditions.
A new study finds that a genetic variation that evolved in the last 250,000 years, after the divergence of humans from ancient hominids, likely plays an important role in disease.
Muslim terrorists and the Klu Klux Klan share one thing in common; they claim to be religious even though the ideas they promote (and in the case of the former, the actions they take) are not very nice.
The fringes get all of the attention but most religious people are not clinically insane or promoting the deaths of others in order to secure their own place in Heaven, and if you remind them of their religious principles, their attitude toward negative events change, according to a paper in the Journal of Personality and Social Psychology.
Obesity was once only for the wealthy, then it was only for Americans and the science engine that made food cheap for all, but now globalization has made it possible for the rich and poor worldwide to be fat - which brings greater risk of suffering a heart attack, stroke and diabetes.
No one wants to eat less delicious food, but they would take a pill to shed fad and a team ed by Professor Alexander Pfeifer from the University Hospital Bonn believe they have come one step closer to that. They have found that a signaling molecule can stimulate brown fat and burn energy from food: The body's own adenosine activates brown fat and "browns" white fat.
Though lots of people used the expensive government health insurance portal healthcare.gov to get information on the Affordable Care Act, also called Obamacare, far fewer could successfully use it to sign up.
As the stories of its flaws mounted, larger percentages instead talked to call centers or a navigator without using the website at all. That's a win for the government, which needed to show some success after expending a great deal of political capital and taxpayer money, but not without cost. How much cost is unclear, the government has not yet disclosed how many people signed up and actually paid anything, or how many stopped when they discovered that on top of payments they now had $4,000 a year deductibles.
It seems counter-intuitive that in order to survive best as a species, not everything can live forever, but some cells in our bodies are fated to die, and a Mission Impossible-style auto-destruct program insures they do.
This elaborate cell death program, known as apoptosis, got a little more insight with a study on the evolution of caspase-8, a key cell death initiator molecule that was first identified in humans. By performing the most extensive evolutionary analysis of the Casp8 protein to date,
Sakamaki et. al.,
write in Molecular Biology and Evolution
A recent model says it provides the first characterization of the progenitor for a hydrogen-deficient supernova. Their simulation predicts that a bright hot star, which is the binary companion to an exploding object, remains after the explosion so they secured observation time with the Hubble Space Telescope (HST) to search for such a remaining star.
Unless you are trapped at a Larry Summers protest at Harvard in 2006, you know that male and female brains are not equal in all ways.
Another study affirms that, finding a difference when it comes to the biological response to a high-fat diet. Cedars-Sinai Diabetes and Obesity Research Institute scientist Deborah Clegg, PhD, and colleagues found that the brains of male laboratory mice exposed to the same high-fat diet as their female counterparts developed brain inflammation and heart disease that were not seen in the females.
Reading glasses have served us for centuries. Why fix a good thing? Because science and technology can.
Presbyopia, blurriness in near vision experienced by many people over the age of 40, could one day be relegated to olden days if a thin ring inserted into the eye gains popularity.
A new study has found that people who play action video games such as the "Call of Duty" or "Assassin's Creed" seem to learn a new sensorimotor skill faster than non-gamers do. Sorry, Bungie, "Destiny" was not out when they did the study and auto-rifles would mess up the results anyway.
A new sensorimotor skill, such as learning to ride a bike or typing, often requires a new pattern of coordination between vision and motor movement. With such skills, an individual generally moves from novice performance, characterized by a low degree of coordination, to expert performance, marked by a high degree of coordination. As a result of successful sensorimotor learning, one comes to perform these tasks efficiently and perhaps even without consciously thinking about them.
When most people think of first responders, they think of paramedics or combat medics or other medically-trained personnel doing CPR and other life-saving procedures in stressful situations. They do not think of acupuncture. A review article in Medical Acupuncture - since it is a review, it is collating other articles about acupuncture, rather than science or medicine - argues that first responders should be trained in integrative medicine approaches such as acupuncture, hypnosis and biofeedback to provide adjunctive treatment to help relieve patients' pain and stress. Maybe they could teach some yoga and the benefits of organic food during the next earthquake as well.
