Scientists have reported that an experimental vaccine targeting one of the most common genetic drivers of pancreatic cancer, called mutant KRAS, is safe and generated a durable immune responses aimed at preventing the cancer.
When E. F. Thompson stood on the deck of a ship cruise ship the Indian Ocean in the 1930s and observed a dolphin speed past the vessel in 7 seconds, he had no idea that this single observation would lead Sir James Gray to formulate the enduring paradox that bears Gray's name to this day.
Based on Thompson's anecdote, Gray estimated the power required to propel the boisterous mammal through the waves at 20 knots (10.3 m/s) and concluded that the animal did not have enough muscle to pull off the feat. Puzzled by the paradox, Gray concluded that dolphins must use a trick of fluid mechanics to sustain the remarkable performance.
A new study by shows a direct link between metabolism in brain cells and their ability to signal information. The research may explain why the seizures of many epilepsy patients can be controlled by a specially formulated diet.
The findings in Nature Communications by scientists at McGill University and the University of Zurich reveal that metabolism controls the processes that inhibit brain activity, such as that involved in convulsions. The study uncovers a link between how brain cells make energy and how the same cells signal information – processes that neuroscientists have often assumed to be distinct and separate.
The Subaru Telescope, an 8.2-meter telescope operated by the National Astronomical Observatory of Japan, has been combing the night sky since 1999. Located at the Mauna Kea Observatories in Hawaii, the telescope has been systematically surveying each degree of space, whether it looks promising or not, in search of objects worthy of further investigation. One of the most fascinating objects to emerge from the Subaru Telescope's wide-field survey—Himiko—was discovered in 2009. Himiko, a "space blob" named after a legendary queen from ancient Japan, is a simply enormous galaxy, with a hot glowing gaseous halo extending over 55,000 light-years.
Glaciers are important indicators of climate change. Global warming causes mountain glaciers to melt, which, apart from the shrinking of the Greenlandic and Antarctic ice sheets, is regarded as one of the main causes of the present global sea-level rise. Tibet's glaciers are also losing mass clearly, as scientists from the universities of Zurich, Tubingen and Dresden reveal using satellite-based laser measurements.
This news release is available in German.
This news release is available in German.
The structure of the human brain is complex, reminiscent of a circuit diagram with countless connections. But what role does this architecture play in the functioning of the brain? To answer this question, researchers at the Max Planck Institute for Human Development in Berlin, in cooperation with colleagues at the Free University of Berlin and University Hospital Freiburg, have for the first time analysed 1.6 billion connections within the brain simultaneously. They found the highest agreement between structure and information flow in the "default mode network," which is responsible for inward-focused thinking such as daydreaming.
This news release is available in German.
The survivors of a stroke often struggle with persistent loss of function of the central nervous system. Around the world strokes are one of the most frequent causes of paresis. Physiotherapy or occupational therapy can restore a certain degree of mobility. However, a patient with severe paresis, for instance of an arm, can only recover limited function through these therapeutic exercises.
Researchers at the RIKEN-MIT Center for Neural Circuit Genetics and MIT's Picower Institute for Learning and Memory have discovered a new brain circuit that shapes memory formation by endowing neurons with the ability to connect two events separated in time into a single experience.
In a study appearing in the journal Science a research team lead by Dr. Susumu Tonegawa, MIT Professor and Director of the RIKEN Brain Science Institute report the discovery of Island cells and a new brain circuit responsible for limiting the brain's ability to link two events that happen seconds or minutes apart into one experience, a property of memory called temporal association.
As the male túngara frog serenades female frogs from a pond, he creates watery ripples that make him easier to target by rivals and predators such as bats, according to researchers from The University of Texas at Austin, the Smithsonian Tropical Research Institute (STRI), Leiden University and Salisbury University.
A túngara frog will stop calling if it sees a bat overhead, but ripples continue moving for several seconds after the call ceases. In the study, published this week in the journal Science, researchers found evidence that bats use echolocation — a natural form of sonar — to detect these ripples and home in on a frog. The discovery sheds light on an ongoing evolutionary arms race between frogs and bats.
The linchpin location of the "Star Wars" franchise was the planet Tatooine, home to both Luke Skywalker and Obi-Wan Kenobi. It, along with its twin suns, appeared in every movie of the franchise except "The Empire Strikes Back".
How would such a planet, orbiting two stars, form? There are few environments more extreme than a binary star system, if you are forming a planet.
Kepler-34(AB)b has some answers, according to a new study. Like Tatooine, Kepler-34(AB)b is a circumbinary planet, its orbit encompasses two stars. Since powerful gravitational perturbations from two stars lead to destructive collisions that grind down planetary material, the existence of such planets can be difficult to explain.
A new study conservatively estimates that one in five women with ovarian cancer has inherited genetic mutations that increase the risk of the disease, according to research at Washington University School of Medicine in St. Louis.
Most women in the study would have been unaware of a genetic predisposition to ovarian cancer because they didn't have strong family histories that suggested it.
Silicon-based electronics has certain limits, in the physical sense of the word: this type of circuit can never become "nano" because of the physical laws governing the flow of electrons. This imposes a halt to the process of miniaturization of electronic devices. One of the possible solutions is to use molecules as circuits, but their poor conduction capabilities make them unlikely candidates. There is, however, a possible way around this, which was investigated in a recent paper published in Proceedings of the National Academy of Sciences (PNAS) by an international research team that includes Ryan Requist, Erio Tosatti and Michele Fabrizio of the International School for Advanced Studies (SISSA) in Trieste.
