In Current Biology, Instituto Gubenkian de Ciencia researchers say they have provided insight into an old mystery in cell biology- and maybe it will offer up new clues to understanding cancer. Inês Cunha Ferreira and Mónica Bettencourt Dias, working with researchers at the universities of Cambridge, UK, and Siena, Italy, say they have unravelled the mystery of how cells count the number of centrosomes, the structure that regulates the cell's skeleton and controls the multiplication of cells, and is often transformed in cancer.This research addresses an ancient question: how does a cell know how many centrosomes it has? It is equally an important question, since both an excess or absence of centrosomes are associated with disease, from infertility to cancer.