Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Temperatures are rising on Earth, which is heating up the debate over global warming and the future of our planet, but what may be needed most to combat global warming is a greater focus on adapting to our changing planet, says a team of science policy experts writing in this week's Nature magazine.
While many consider it taboo, adaptation to global climate change needs to be recognized as just as important as "mitigation," or cutting back, of greenhouse gases humans pump into Earth's atmosphere. The science policy experts, writing in the Feb.
In recent years, scientists have discovered that a family of enzymes called sirtuins can dramatically extend life in organisms as diverse as yeast, worms, and flies. They may also be able to control age-associated metabolic disorders, including obesity and type II diabetes.
Naturally occurring substances have been shown to activate sirtuins, including a constituent of red wine called resveratrol -- although an individual would need to drink about two cases of wine a day to derive a clinically effective dose of resveratrol. Still, the findings have energized a number of scientific groups and biotechnology companies, all of which are now eagerly searching for drug candidates able to boost sirtuin activity.
According to a recent paper published by MBARI geologists and their colleagues, methane gas bubbling through seafloor sediments has created hundreds of low hills on the floor of the Arctic Ocean. These enigmatic features, which can grow up to 40 meters (130 feet) tall and several hundred meters across, have puzzled scientists ever since they were first discovered in the 1940s.
This conceptual drawing (not to scale) shows Paull's hypothesis that methane gas from deep hydrate deposits could push sediment up from below the ocean bottom to create a pingo-like feature. The gray lines in the background are from a seismic profile through one of these enigmatic features. (Image: Copyright 2007 MBARI)
Cancer cells are sick, but they keep growing because they don't react to internal signals urging them to die. Now researchers at Washington University School of Medicine in St. Louis have found an efficient way to get a messenger into cancer cells that forces them to respond to death signals. And they did it using one of the most sinister pathogens around — HIV.
"HIV knows how to insert itself into many different types of cells," says senior author William G. Hawkins, M.D., assistant professor of surgery and a member of the Siteman Cancer Center at the School of Medicine and Barnes-Jewish Hospital. "A portion of the HIV protein called TAT can transport biologically active compounds into cells. TAT is small, but it can move massive molecules.
Physicists at JILA have demonstrated that the warmer a surface is, the stronger its subtle ability to attract nearby atoms, a finding that could affect the design of devices that rely on small-scale interactions, such as atom chips, nanomachines, and microelectromechanical systems (MEMS).
JILA scientists measured how temperature affects the Casimir-Polder force using an apparatus that holds four small squares of glass inside a vacuum chamber. A cloud of ultracold atoms in a Bose-Einstein Condensate (BEC) was held a few micrometers below one piece of glass, and the force was calculated based on the wiggling of the BEC. Warmer glass magnified the attraction between the surface and the atoms. (Credit: E.
Two biologists at Penn State have discovered a master regulator that controls metabolic responses to a deficiency of essential amino acids in the diet. They also discovered that this regulatory substance, an enzyme named GCN2 eIF2alpha kinase, has an unexpectedly profound impact on fat metabolism. "Some results of our experiments suggest interventions that might help treat obesity, prevent Type II diabetes and heart attacks, or ameliorate protein malnutrition," said Douglas Cavener, professor and head of the Department of Biology, who led the research along with Feifan Guo, a research assistant professor.
Physicists have for the first time stopped and extinguished a light pulse in one part of space and then revived it in a completely separate location. They accomplished this feat by completely converting the light pulse into matter that travels between the two locations and is subsequently changed back to light.
Matter, unlike light, can easily be manipulated, and the experiments provide a powerful means to control optical information.
A study at UCL (University College London) finds that a high-prevalence of male-killing bacteria active in many species of insect including the butterfly, actually increases female promiscuity and male fatigue.
The study was carried out on Hypolimnas bolina butterflies in Pacific Island and South-East Asian populations. The islands provide an ideal location because every island is differently affected by the male-killling bacteria so that each has a different ratio of males to females. (Photo Credit: Sylvain Charlat, UCL)
The largest climate change in central North America since the age of the dinosaurs 65 million years ago, a temperature drop of nearly 15 degrees Fahrenheit, is documented within the fossilized teeth of horses and other plant-eating mammals, a new study reveals.
The overwhelming majority of previous climate-change studies on the 400,000-year transition from the Eocene to the Oligocene epochs, about 33.5 million years ago, focus on marine environments, but University of Florida vertebrate paleontologist Bruce MacFadden and his colleagues turned their attention to fossils from the Great Plains.
University of Florida vertebrate paleontologist Bruce MacFadden examines a fossil oreodont jaw from Nebraska in the Florida Museu
New research findings may help refine the accepted models used by earth scientists over the past 30 years to describe the ways in which continents clash to form the Earth's landscape.
Eric Calais, an associate professor of geophysics at Purdue University, in collaboration with Ming Wang and Zenghang Shen from the Institute for Geology and Earthquake Science in China, used global positioning systems to record the precise movements of hundreds of points on the continent of Asia over a 10-year period.
A new analysis led by an MIT scientist describes a mechanism for capturing carbon dioxide emissions from a power plant and injecting the gas into the ground, where it would be trapped naturally as tiny bubbles and safely stored in briny porous rock.
This means that it may be possible for a power plant to be built in an appropriate location and have all its carbon dioxide emissions captured and injected underground throughout the life of the power plant, and then safely stored over centuries and even millennia.
Pity the molecular biologist.
The object of fascination for most is the DNA molecule. But in solution, DNA, the genetic material that hold the detailed instructions for virtually all life, is a twisted knot, looking more like a battered ball of yarn than the famous double helix.