In the 1980s, scientists captured the precise mechanics of a protein machine. It looked strange, to researchers its tall thin structure with stubby legs invoked the enchanted broomstick that stole the show in "The Sorcerer's Apprentice" segment of Disney's 1940 Fantasia film.
Researchers are on the verge of developing a new class of anesthetics, something that has not happened in decades, according to a study published in Anesthesiology. It is being derived thanks to a new approach to identifying compounds may lead to the next generation of anesthetics.
Positional cloning is a genetic mapping technique used to pinpoint the location of specific traits of interest, such as disease-causing genes or mutations, within the genome. Very simply, this map-based technique involves crossing mutant individuals with wild-type individuals and examining the offspring in order to localize a candidate region in the genome for the mutation. By identifying genetic markers that are linked to the trait, progressively more precise areas on a chromosome are defined until the gene is identified.
This approach has contributed to the successful mapping of genes involved in numerous human diseases such as Huntington's disease and cystic fibrosis, an important first step in understanding these conditions.
A research team has discovered a molecular "rheostat" in the brain's appetite control center that may provide new insights into obesity, which is at epidemic levels in this country.
The discovery of this novel cell signaling pathway, reported today in the journal Nature, revises the previous "on-off" switch model of appetite control, said Roger Cone, Ph.D., who led the research team with Masoud Ghamari-Langroudi, M.D., Ph.D.
The discovery centers on a receptor in the brain's appetite control center, the melanocortin-4 receptor, or MC4R, a G-protein coupled receptor (GPCR) embedded in the membranes of nerve cells.
Acute kidney injury often arises after major surgery because the kidneys can be deprived of normal blood flow during the procedure. The use of contrast media, or dyes, can contribute to this problem.
In patients undergoing coronary angiography or percutaneous coronary intervention, which are heart procedures that use dyes to help surgeons visualize the arteries, a high dose of the statin atorvastatin was linked with a reduction in blood levels of creatinine, a marker of kidney injury, as well as a lower incidence of acute kidney injury compared with a low dose of the statin.
Sometimes the whole is greater than the sum of its parts, said Aristotle. That certainly applies to biology, where molecular motions in living systems have a macroscale effect - such as large muscles that contract due to protein motors.A team at CNRS's Institut Charles Sadron led by Nicolas Giuseppone, professor at the Université de Strasbourg has used this concero to make a polymer gel that is able to contract through the action of artificial molecular motors. When activated by light, these nanoscale motors twist the polymer chains in the gel, which as a result contracts by several centimeters. Another advantage is that the new material is able to store the light energy absorbed.
A recently published study offers new clues about the evolution of the immune system in European populations of the plant Arabidopsis thaliana and the underlying genetic mechanisms associated with immunity. The species Arabidopsis thaliana, which is naturally distributed across the northern hemisphere, belongs to the same family than mustard. The species is used as model in plant biology studies because its genome is relatively small and appropriate for genetic studies.
There is a lot of talk about increasing longevity but 50 years of increasing frailty, doctor visits and overall decline is not really an improvement over 30 years of it.A new study shows that by focusing on the genetics involved in increasing longevity, we won't be helping people much at all; genes that increase longevity may not significantly increase healthy lifespan.A study of long-lived mutant C. elegans by scientists at the University of Massachusetts Medical School shows that the genetically altered worms spend a greater portion of their life in a frail state and exhibit less activity as they age then typical nematodes.
Some groups want to label foods that contain anything created with modern genetic modification. Yet the previous generation of genetically modified foods, using mutagenesis, can be labeled organic. And why not label all pesticides used on food, whether synthetic or organic, if awareness is important? If a Bt genetic modification is important to know about, why isn't Bt spray on organic food important to know about.The only thing less valuable than most proposed labeling changes are the existing labels, according to a new paper - at least if the goal is improving nutrition.
A new species of dinosaur has turned out not to be a dinosaur at all, it is instead one of the large reptiles that lived before dinosaurs took over the world. But like many dinosaurs, it looked fearsome.
Nundasuchus songeaensis was a 9-foot-long carnivorous reptile with steak knife-like teeth, bony plates on the back, and legs that lie under the body.
The basic meaning of Nundasuchus, is "predator crocodile," "Nunda" meaning predator in Swahili, and "suchus" a reference to a crocodile in Greek.
Most dogs and most humans get along well now and anthropological explanations are that selective selection is the reason; wolves that were not a threat were not killed and over time the agreeable ones got shelter and food. That cooperation has led to thousands of years of being man's best friend.Friederike Range and Zsófia Virányi from the Unit of Comparative Cognition at the Messerli Research Institute at University of Veterinary Medicine, Vienna have an alternate idea, the "Canine Cooperation Hypothesis". They believe that since wolves already are tolerant, attentive and cooperative, the relationship of wolves to their pack mates could have provided the basis for today's human-dog relationship.
Some cultural pundits contend that income inequality is linked to parenting inequality but new findings dispute that. You don't have to be wealthy to be involved in your child's life, despite modern thinking, according to a new paper which finds that poorer parents are just as involved in education, leisure and sports activities with their children as wealthier ones.The researchers used the Poverty and Social Exclusion in the UK survey, carried out between March and December 2012. Among the questions it asked were:
How many days in the past seven days have you, or your partner read stories with your child/children or talked with them about what they are reading?
Scientists have analyzed extraterrestrial dust hat has settled on ocean floors to determine the amount of heavy elements created by the massive explosions. The dust is thought to be from supernovae, exploding stars way beyond our solar system, and their conclusions are at odds with current theories of supernovae, in which some of the materials essential for human life, such as iron, potassium and iodine are created and distributed throughout space.
