In the 1980s, scientists captured the precise mechanics of a protein machine. It looked strange, to researchers its tall thin structure with stubby legs invoked the enchanted broomstick that stole the show in "The Sorcerer's Apprentice" segment of Disney's 1940 Fantasia film.
A team of researchers has demonstrated the therapeutic potential of triheptanoin in ten patients with Huntington's disease. Derivatives of this triglyceride, with its unique composition, might be able to slow the progression of the disease by improving the energy metabolism of the brain. This research is published in the journal Neurology.
Huntington's disease is a genetic disease that affects approximately 5,000 people in France, with another 10,000 individuals at risk of developing it. Mutation of the gene encoding the huntingtin protein results in a progressive degeneration of the neurons, especially in regions of the brain involved in the control of movement, thereby causing serious neurological, motor, cognitive and psychiatric problems.
A new paper believes that planets outside our solar system - exoplanets - may be a lot more agreeable to life than assumed. The astrophysicists suggest that exoplanets are more likely to have liquid water and be more habitable than we thought.Scientists have thought that exoplanets behave in a manner contrary to that of Earth - that is they always show their same side to their star. If so, exoplanets would rotate in sync with their star so that there is always one hemisphere facing it while the other hemisphere is in perpetual cold darkness.The new study suggests, however, that as exoplanets rotate around their stars, they spin at such a speed as to exhibit a day-night cycle similar to Earth.
The picture is awesome but are you risking your health? Steve Marcus/Reuter
By Andrew Maynard, University of Michigan
The simple training exercise of catching a weighted medicine ball can improve balance and may help prevent falls in the elderly - and if you have a grandkid that wants to go out in the yard and toss a baseball, it will be good for both of them in many ways.
When someone is jostled by a bump or a stumble, the brain uses two strategies to maintain balance and prevent a fall, says Alexander Aruin, professor of physical therapy at University of Illinois at Chicago and principal investigator on the two studies.
"When the perturbation is predictable, for example, if when walking down the street you see someone about to bump into you, you brace yourself," Aruin said. The brain activates muscles in anticipation of the jolt.
Sepsis is a leading cause of death for patients in intensive care units. The excessive systemic inflammation in individuals with sepsis damages organs and can lead to death.
Therapeutic options for sepsis are limited and the factors that promote this excessive response to infection are poorly understood. A new study in the Journal of Clinical Investigation identifies a metabolic pathway that underlies sepsis inflammation. Augustine Choi and colleagues at Weill Cornell Medical College found that a mitochondrial uncoupling protein, UCP2, is elevated in patients with sepsis. In mouse model of sepsis, lack of this protein improved survival.
No one in the United States or foreign governments like that the Obama administration was caught spying on everyone at unprecedented levels - it was always a 'gentleman's agreement' to use some prudence and not get caught.
When mass murders happen in a place like the US, despite the fact that they are no more prevalent than most countries and murders have plummeted as gun ownership rose, the simplistic answer is 'guns' - when murders happen in Canada or France, where gun ownership is heavily restricted, the answer is not so convenient. It may not be guns forcing people to kill people, it may be attachment to an 'overvalued idea' - and it may become more common.Zehaf-Bibeau, the Islamist convert who murdered a Canadian military reservist on duty in Ottawa, represents a type of attacker rarely discussed--a person so obsessed with an overvalued idea that it defines their identity and leads them to commit violence without regard for the consequences.
Air Force reservists based in the U.S. who worked after the Vietnam War in C-123 aircraft that sprayed Agent Orange during the war could have experienced adverse health effects from exposure to the herbicide, says a new report from the Institute of Medicine. The reservists who served in the contaminated C-123s experienced some degree of exposure to the toxic chemical component of Agent Orange known as TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), and it is plausible, in some cases, that the reservists exceeded TCDD exposure guidelines for workers in enclosed settings.
Gine Roll Skjaervoe at the Norwegian University of Science and Technology's (NTNU) Department of Biology has studied church records from the period 1750-1900 and looked at life history variables: how old were women when they had their first child, and their last? How many years passed between the birth of each child, and how many of these children survived? How many of these children were in turn married and had children?
All told, she studied information from more than 9,000 people listed in the church records she examined.
A man-made form of insulin delivered by nasal spray may improve working memory and other mental capabilities in adults with mild cognitive impairment and Alzheimer's disease dementia, according to a pilot study led by researchers at Wake Forest Baptist Medical Center.
The study's subjects were 60 adults diagnosed with amnesic mild cognitive impairment (MCI) or mild to moderate Alzheimer's dementia (AD). Those who received nasally-administered 40 international unit (IU) doses of insulin detemir, a manufactured form of the hormone, for 21 days showed significant improvement in their short-term ability to retain and process verbal and visual information compared with those who received 20 IU does or a placebo.
The debate over policy implications of climate science can have no clear winners - everyone claims science is on their side and that scientists on the other side are misguided. Though both sides are experts at framing - CO2 is good for us in any quantity, skeptics are all dupes of Big Oil - one was clearly taking it to the next level: In 2000, Professor Paul Crutzen, who won the 1995 Nobel Prize in Chemistry with Mario Molina and Sherwood Rowland for work on ozone, said humankind's impact was so drastic it has changed the actual geology of Earth and since then environmentalist have been promoting Crutzen's new Epoch - the Anthropocene - as a distinct chapter in the Earth's geological history.
Scientists have extracted DNA from mysterious marsupial megafauna that roamed Australia over 40,000 years ago - Australia's extinct giant kangaroos.The team extracted DNA sequences from two species: a giant short-faced kangaroo (Simosthenurus occidentalis) and a giant wallaby (Protemnodon anak). These specimens died around 45,000 years ago and their remains were discovered in a cold and dry cave in Tasmania.Relatively good preservation conditions in the cave allowed enough short pieces of DNA to survive so researchers could reconstruct partial "mitochondrial genomes" - genetic material transmitted from mother to offspring and widely used to infer evolutionary relationships.
