In the 1980s, scientists captured the precise mechanics of a protein machine. It looked strange, to researchers its tall thin structure with stubby legs invoked the enchanted broomstick that stole the show in "The Sorcerer's Apprentice" segment of Disney's 1940 Fantasia film.
Researchers at the Montreal Heart Institute announced today results showing that patients with cardiovascular disease and the appropriate genetic background benefit greatly from the new medication dalcetrapib, with a reduction of 39% in combined clinical outcomes including heart attacks, strokes, unstable angina, coronary revascularizations and cardiovascular deaths. These patients also benefit from a reduction in the amount of atherosclerosis (thickened walls) in their vessels. The detailed results are published in the prestigious Journal Circulation Cardiovascular Genetics. This discovery may also pave the way for a new era in cardiovascular medicine, with personalized or precision drugs.
Sex or no sex? If you want to be healthier as a species over time, sexual reproduction is the way to go, according to a new study.
It's a long-debated topic among biologists - some argue that sexual reproduction is superior because species don't accumulate harmful mutations as easily as in asexual reproduction.
Using various species of the evening primrose (Oenothera) as his model, Dr. Jesse Hollister, assistant professor at Stony Brook University in New York, and colleagues demonstrated strong support for reproducing sexually. "These findings allow us to understand why an enormous diversity of species around the world go through the laborious process of sexual reproduction," says Hollister.
Engineers in Austria have given us a blessing and a curse - they have created a giant laser system that sends beams in different directions, which makes them visible from many different angles. The angular resolution is so fine that the left eye is presented a different picture than the right one, creating a 3D effect.
On November 23rd, 2014, a new volcano eruption commenced on Fogo, one of the Cape Verde Islands, and it continues even now, making it the largest and most damaging eruption - and the biggest natural disaster no one in the western world was reading about it - on the archipelago for over 60 years. Most of the damage was caused by lava flows advancing into populated regions and numerous buildings, homes and roads were destroyed. In total, three villages have been abandoned and thousands of residents were evacuated.
Scientists have developed a new biosensor that allows them to see, in real time, what happens when a plant’s defenxe system swings into action.When plants come under attack internal alarms signal and their defense mechanisms swing into action. For the first time, plant scientists have imaged, in real time, what happens when plants beat off the bugs and respond to disease and damage.Malcolm Bennett, Professor in Plant Science at The University of Nottingham and Director of the Centre for Plant Integrative Biology, said, “Understanding how plants respond to mechanical damage, such as insect attack, is important for developing crops which cope better under stress.”
Land-based plants respond to hormones in order to survive and it was once assumed that such hormone signaling machinery only existed in these relatively complex plants but new research shows that some types of freshwater algae can also detect ethylene gas - the same stress hormone found in land plants - and might use these signals to adapt to changing environmental conditions.
Interbreeding of two malaria mosquito species in the West African country of Mali has resulted in a "super mosquito" hybrid that's resistant to insecticide-treated bed nets.
Anopheles gambiae, a major malaria vector, is interbreeding with isolated pockets of another malaria mosquito, A. coluzzii. Entomologists initially considered them as the "M and S forms" of Anopheles gambiae. They are now recognized as separate species. Interbreeding of two malaria mosquito species in the West African country of Mali has resulted in a "super mosquito" hybrid that's resistant to insecticide-treated bed nets.
A new study identifies the BCL11A gene is especially active in aggressive subtypes of breast cancer. The research suggests that an overactive BCL11A gene drives triple-negative breast cancer development and progression. The research, which was done in human cells and in mice, provides new routes to explore targeted treatments for this aggressive tumor type.
There are many types of breast cancers that respond differently to treatments and have different prognoses. Approximately one in five patients is affected by triple-negative breast cancer; these cancers lack three receptor proteins that respond to hormone therapies used for other subtypes of breast cancer. In recent years it has become apparent that the majority of triple-negative tumors are of the basal-like subtype.
For patients with spinal stenosis, long-term outcomes are comparable with surgery or conservative treatment, according to a new study.
While earlier reports suggested an advantage of surgery, the updated analysis finds no significant difference in pain, functioning, of disability at eight years' follow-up, report Dr Jon D. Lurie and colleagues of Dartmouth-Hitchcock Medical Center, Lebanon, N.H. The results--representing the largest and highest-quality study to date--provide new evidence on what patients can expect several years after deciding whether or not to have or not have surgery for spinal stenosis.
Better Initial Results with Spinal Stenosis Surgery...
Dolphins and seals have had eons to adapt to aquatic life, but they can still be taxed while pushing the boundaries, according to a paper in Nature Communications which found a surprisingly high frequency of heart arrhythmias in bottlenose dolphins and Weddell seals - at least during their deepest dives.
Two miles below the surface of the ocean, researchers have discovered new microbes that "breathe" sulfate. These microbes, which have yet to be classified and named, exist in massive undersea aquifers -- networks of channels in porous rock beneath the ocean where water continually churns.
About one-third of the Earth's biomass is thought to exist in this largely uncharted environment.
Sulfate is a compound of sulfur and oxygen that occurs naturally in seawater. It is used commercially in everything from car batteries to bath salts and can be aerosolized by the burning of fossil fuels, increasing the acidity of the atmosphere.
Evidence from some wrongful-conviction cases suggests that suspects can be questioned in ways that lead them to falsely believe in and confess to committing crimes they didn't actually commit. The new work provides lab-based evidence for this phenomenon, showing that innocent adult participants can be convinced, over the course of a few hours, that they had perpetrated crimes as serious as assault with a weapon in their teenage years. The research in Psychological Science indicates that the participants came to internalize the stories they were told, providing rich and detailed descriptions of events that never actually took place.
