Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
What influence does the variation in estrogen level have on the activation of the female brain? Using functional Magnetic Resonance Imaging, Jean-Claude Dreher, a researcher at the Cognitive Neuroscience Center (CNRS/Université Lyon 1), in collaboration with an American team from the National Institute of Mental Health (Bethesda, Maryland) directed by Karen Berman, has identified, for the first time, the neural networks involved in processing reward-related functions modulated by female gonadal steroid hormones.
Researchers at the National Institutes of Health have developed an experimental vaccine that could, theoretically, eliminate malaria from entire geographic regions, by eradicating the malaria parasite from an area's mosquitoes.
The vaccine, so far tested only in mice, would prompt the immune system of a person who receives it to eliminate the parasite from the digestive tract of a malaria-carrying mosquito, after the mosquito has fed upon the blood of the vaccinated individual. The vaccine would not prevent or limit malarial disease in the person who received it.
An article describing this work was published on the Web site of Proceedings of the National Academy of Sciences.
Scientists at Cardiff University (Wales, UK) have confirmed what thousands of people with arthritis have believed for years. Cod Liver Oil really is effective in treating joint pain and can slow, even reverse, the destruction of joint cartilage.
Cartilage is the ‘gristle’ that cushions bones and prevents them from grinding against each other. Loss of cartilage leads to osteoarthritis, the painful and disabling condition experienced by 1.5 million people in the UK and the major reason for joint replacement surgery.
Each holiday season, another woman who loves the rock band No Doubt will receive a plaid skirt that only the band's singer, Gwen Stefani, could pull off. Another athletic guy will receive an oversize sports jersey – even though off the field he prefers Brooks Brothers. Why are we so terrible at predicting the tastes of the ones we love? A new study explains why familiarity with another person actually makes predicting their tastes more difficult.
Past research has argued that lack of diagnostic information causes this sort of misperception, but Davy Lerouge (Tilburg University, the Netherlands) and Luk Warlop (Katholieke University, Belgium) found that we buy unwanted gifts even when we have plenty of knowledge.
Despite research efforts to find modern factors that would explain the different life expectancies of men and women, the gap is actually ancient and universal, according to University of Michigan researchers.
"Women live longer in almost every country, and the sex difference in lifespan has been recognized since at least the mid-18th century," said Daniel J. Kruger, a research scientist in the U-M School of Public Health and the Institute for Social Research. "It isn't a recent trend; it originates from our deep evolutionary history."
Although women consume less alcohol than men, they are more susceptible to some of the negative medical consequences of alcohol use, such as cirrhosis of the liver, cardiac disease, and cognitive impairments. Animal studies have also shown that males and females differ on behavioral as well as electrophysiological measures of alcohol's effects.
Second-hand smoke, also known as environmental tobacco smoke or ETS, is clearly associated with cancer, respiratory and cardiovascular disease in humans. Several studies have shown that up to 20 different carcinogens contained in tobacco smoke can be inhaled by non-smoking bystanders.
Dr. Timothy Fan, veterinary oncologist at the University of Illinois Veterinary Teaching Hospital in Urbana, explains that although associations between ETS and diseases in animals have not been as extensively researched, a handful of studies show a correlation between ETS and certain forms of cancer in pets.
Cats living in homes where people smoke cigarettes are more than twice as likely as other cats to acquire a deadly form of cancer known as feline lymphoma, according to a first-of-its kind study in cats conducted by scientists at Tufts University School of Veterinary Medicine and the University of Massachusetts.
The study, entitled "Environmental Tobacco Smoke and Risk of Malignant Lymphoma in Pet Cats," was published in the American Journal of Epidemiology. The authors conclude that these findings offer a compelling reason for further study of the relationship between passive smoke and non-Hodgkins lymphoma in humans, which is similar to lymphoma in cats.
A drug commonly used to treat severe acne can lead to depressive behaviour in mice, according to research published in the journal Neuropsychopharmacology.
Since the drug’s introduction in the early 1980s there have been controversial reports of depression and suicidal behaviour that may have occurred in some people taking Roaccutane (Accutane in the US).
This has led to the drug’s manufacturers, Roche, including a warning in the product information that taking the medication may cause depression, psychosis and suicidal behaviour.
Electrical deep brain stimulation can dramatically alleviate depression that is resistant to other treatments, researchers have found in an initial study on six patients. The finding is important, they said, because up to 20 percent of patients with depression fail to respond to standard treatments--requiring combinations of antidepressant drugs, psychotherapy, and electroconvulsive treatment (ECT) that still may fail. The number of resistant depression patients can be large, since depression is the leading source of disability in adults under age 50 in North America.
Researchers at the University of Toronto and The Toronto Hospital have discovered a biological basis for the phantom sensations that are frequently experienced on the missing limbs of amputees. The findings of the study are published in the Jan. 22 issue of Nature.
The researchers found that the neurons in the brain that used to represent sensation in the lost limb were still functional but now driven by the stimulation of other body parts, usually the part of the body closest to the amputated limb. The investigators also found that in patients experiencing phantom pain, the sensation can be recreated by stimulating within the brain. Phantom sensations could not be elicited, however, in amputees without a history of phantom sensations.
A study of follow-up care for patients with unsatisfactory outcomes from deep brain stimulation (DBS) surgery for movement disorders offers insights into reasons for problems and proposes strategies for improved outcomes. The study is posted online today and will appear in the August print issue of Archives of Neurology, one of the JAMA/Archives journals.
According to background information in the article, since the Food and Drug Administration approved deep brain stimulation for the treatment of Parkinson's disease, essential tremor and dystonia (uncontrolled muscle movement), there has been a surge in the number of centers offering this surgical procedure, which involves implanting a device to deliver mild electrical stimulation to block the brain signals that cause tremor. There is currently no consensus regarding appropriate screening procedures, necessary training of individuals providing the therapy, the need for an interdisciplinary team, or guidelines for the management of complications, the authors report.